Pharmacokinetic Models Of Tumor Targeting

建立了数学模型来描述单克隆抗体大剂量全身给药后血管前球形肿瘤结节和周围正常组织中抗体浓度的时间过程。这些模型旨在用于设计和评估在检测或治疗癌症微转移时使用抗体的方案。该模型纳入了以下影响正常和肿瘤组织中抗体水平的因素：血浆动力学、经毛细血管转运、淋巴清除以及结合反应和扩散引起的抗体浓度的空间变化。采用有限元法对微分方程进行了说明性数值模拟。进行敏感性分析，以确定影响方案效用的重要参数。

Mathematical models were developed to describe the time course of antibody concentrations in a prevascular spherical tumor nodule and the surrounding normal tissue following bolus systemic administration of monoclonal antibody. The models are intended for use in designing and evaluating protocols for the use of antibodies in detection or treatment of cancer micrometastases. The models incorporate the following factors that affect antibody levels in the normal and tumor tissues: plasma kinetics, transcapillary transport, lymphatic clearance, and spatial variation in antibody concentration arising from binding reactions and diffusion. Illustrative numerical simulations were performed employing finite element methods to solve the differential equations. Sensitivity analyses were conducted to identify the parameters whose magnitude would be important in influencing the utility of the protocols.