Alcohol, Mortality and Ethnicity in the US

描述（由申请人提供）：访谈调查（NHIS）提供了一个独特的机会，探索美国不同种族群体中酒精消费的不同维度与全因和特定原因死亡率之间的关系。HI：总体而言，45岁以上人群的平均饮酒量与全因死亡率之间将呈现J形曲线，而年轻人则呈现线性曲线。H2：大量饮酒的饮酒模式不会对全因死亡率产生有益影响。H3-4：平均饮酒量与全因死亡率之间的关系将根据各自的饮酒模式具体到种族。H5-7：由于大量饮酒与冠心病和损伤有关，这些死亡原因的原因特异性死亡率具有种族特异性，而对于癌症，预计平均饮酒量与种族之间没有这种相互作用。NHIS是对美国平民、非制度化人口的代表性横断面调查。在1988年和1990年的NHIS中，所有18岁及以上的成年人都有婚姻状况和潜在的死亡原因，随访至1997年12月31日。基线样本将包括81，464名男性（n= 33，989）和女性（47，475），其中5，585名西班牙裔男性（n= 2，303）和女性（3，282）以及11，253名非西班牙裔黑人男性（n= 3，983）和女性（7，270）。沉没的约8年的随访将包括总共8，294例死亡，302例西班牙裔死亡和1，223例非西班牙裔黑人死亡。这将是迄今为止用于调查美国主要少数群体酒精摄入量与死亡率之间关系的最大代表性美国样本。一旦确定样本的同质性，将对合并数据使用比例风险回归模型。研究结果将为制定针对种族的预防措施以避免与酒精相关的疾病负担提供重要的背景数据。

DESCRIPTION (provided by applicant): Interview Survey (NHIS) offer a unique chance to explore the relationships between different dimensions of alcohol consumption with all-causes & cause-specific mortality in different ethnic groups in the US. The following specific hypotheses will be tested: HI: Overall, there will be a J-shaped curve between average volume of alcohol consumption & all-cause mortality in people over 45 years of age, & a linear curve in younger persons. H2: A drinking pattern with heavy drinking occasions will confer no beneficial effects on all-causes mortality. H3-4: The relationships between average volume of alcohol consumption & all-causes mortality will be specific to ethnicity, based on the respective drinking patterns. H5-7: As heavy drinking occasions are relevant for Coronary Heart Disease & injuries, the cause specific mortality for those causes of death with be ethnic group specific, whereas for cancers no such interaction between average volume of alcohol consumption and ethnicity is expected. The NHIS is a representative cross-sectional survey of the civilian, non-institutionalized US population. For the1988 & 1990 NHIS, marital status & underlying cause of death are available for all adults18 years & older with follow-up through 12/31/97. The baseline sample will include 81,464 men (n=33,989) & women (47,475) with 5,585 Hispanic men (n=2,303) & women (3,282) & 11,253 non-Hispanic Black men (n=3,983) & women (7,270). The approx. 8 years of follow-up will include a total of 8,294 deaths, 302 Hispanic deaths and 1,223 deaths in non-Hispanic Blacks. This will be the largest representative US sample to date used to investigate the association between dimensions of alcohol intake & mortality in the major US minority groups. Proportional hazard regression models will be used on the combined data, once homogeneity of samples is established. The results will provide important background data for shaping ethnicity-specific preventive measures for avoiding alcohol-related burden of disease.