MEMORY DISTORTION IN ALZHEIMER'S DISEASE

这是一份以病人为导向的职业发展指导奖(K-23)的申请书，题为“阿尔茨海默氏症中的记忆扭曲”。这位候选人感兴趣的是阿尔茨海默氏症中认知能力下降的研究，特别强调记忆扭曲。记忆的扭曲会削弱可能患有阿尔茨海默病(AD)的患者独立生活的能力。这位候选人建议测试他之前的研究产生的假设，以更好地理解这些记忆扭曲的原因。候选人之前的培训是痴呆症和神经学的临床方面，他在NIMH赞助的国家研究服务奖的指导下接受了认知神经科学的初步培训，指导是Daniel L.Schacter博士。拟议的项目将在(1)认知神经科学和(2)行为实验的设计和分析方面提供更高级的培训，以及(3)认知事件相关电位(ERP)实验的设计和分析培训。为实现这些目标而设计的研究项目整合了几种实验方法来研究错误识别，错误识别是AD中发生的一种记忆扭曲。首先，将在AD患者中使用行为范式，以了解候选人之前使用语义关联词的错误识别结果是否可以推广到其他类型的项目。其次，行为范式也将被用于AD患者和局灶性脑部病变，以更好地了解记忆的哪些部分以及哪些大脑结构导致AD患者的错误识别。第三，将对AD患者的事件相关电位进行检测，以探索真假识别的电生理关联。统计学和认知神经科学的教学课程将补充研究工作。这一综合计划提供行为实验、电生理(ERP)技术和认知神经科学方面的培训，将促进候选人发展成为阿尔茨海默病和行为神经学领域的独立研究员。这项研究将促进我们对阿尔茨海默病患者记忆及其扭曲的理解，并可能为健康人的编码和提取提供见解。

This is an application for a Mentored Patient-Oriented Career Development Award (K-23) entitled "Memory Distortion in Alzheimer's Disease." The candidate's interest is in the study of the cognitive decline that occurs in Alzheimer's disease, with a particular emphasis on memory distortion. Distortions of memory can impair the ability of the patient with probable Alzheimer's disease (AD) to live independently. The candidate proposes to test hypotheses generated from his previous study to better understand the cause of these memory distortions. The candidate's previous training was in clinical aspects of dementia and neurology, and he has had initial training in cognitive neuroscience from an NIMH-sponsored National Research Service Award under the direction of Daniel L. Schacter, Ph.D. The proposed project will provide more advanced training in (1) cognitive neuroscience and (2) the design and analysis of behavioral experiments, as well as training in (3) the design and analysis of cognitive event-related potential (ERP) experiments. The research project designed to achieve these goals integrates several experimental approaches to study false recognition, a type of memory distortion that occurs in AD. First, behavioral paradigms will be used in AD patients to understand whether the candidate's previous false recognition findings using semantically associated words can be generalized to other types of items. Second, behavioral paradigms will also be employed in patients with AD and focal brain lesions to better understand which parts of memory and what brain structures contribute to AD patients' false recognition. Third, ERPs of AD patients will be examined to explore electrophysiological correlates of true and false recognition. Didactic courses in statistics and cognitive neuroscience will complement the research work. This integrated program, providing training in behavioral experiments, electrophysiological (ERP) techniques, and cognitive neuroscience, will foster the candidate's development into an independent investigator in the fields of Alzheimer's disease and behavioral neurology. The research conducted will advance our understanding of memory and its distortions in patients with AD, and may provide insights into encoding and retrieval in healthy individuals.