Pathogenesis of Infectious Diseases Training Program

描述（由申请人提供）：该计划的目标是培养医学科学家在生物医学研究，重点是传染病的发病机制。重点将放在世界性的重要疾病上，包括结核病、疟疾、利什曼病、丙型肝炎和艾滋病。 培训计划将利用康奈尔大学威尔医学院的资源（W。约翰逊，E. Cesarman，K. Deitsch，S.埃尔特湖Golightly，J. Ho，C. Nathan，D. Schnappinger，T.邓普顿）、洛克菲勒大学（D. Ho角赖斯河斯坦曼）和亚伦钻石艾滋病研究中心（D。Ho）。该计划的高级教师是资助的科学家，致力于研究和培训。六个新的潜在导师已经被包括在内-所有独立的NIH研究支持。培训教师在通过NIH Fogarty计划研究和培训国际生物医学科学家方面有着悠久的成功合作历史，并将这些经验应用于美国医生科学家的培训。 在目前的供资期间（1999 - 2003年），任命了10名受训人员-4人获得了国家卫生研究院"K"奖或研究补助金，2人提交了该奖或研究补助金。这些奖项的主题领域是KSHV-HHV 8，HIV发病机制，HIV-TB合并感染，HIV疫苗开发，利什曼原虫发病机制和M。结核病-NO相互作用在这些 奖励，主要的T32导师继续作为K奖导师。两名前受训人员正在进行关于艾滋病毒疫苗和生物恐怖主义的研究和培训。最近的两名受训人员正在确定其研究项目（艾滋病毒-结核病相互作用和艾滋病毒-丙型肝炎合并感染）。有3名少数族裔受训人员（2名非洲裔美国人，1名西班牙裔）和3名女性受训人员。 该计划将继续招募已经完成临床培训（医学，儿科，病理学）并正在寻求学术调查职业的医生。培训教师们都认为，医生兼科学家确实是一种濒临灭绝的物种。这项培训补助金将为年轻医生提供从临床培训过渡到实验室的机会。研究培训为期2 - 3年，每年有5名研究员参加。学员将有机会与海地的优秀导师一起工作（D。Fitzgerald，J. Pape）和巴西（E. Carvalho和A. Ko），如果与美国实验室研究有关。海地和巴西的研究重点是艾滋病毒自然史和传播研究、机会性感染（利什曼病、结核病）、流行病学、免疫病理学和干预措施（行为、药物、疫苗）。

DESCRIPTION (provided by applicant): The objective of this program is to train physician-scientists in biomedical research, with an emphasis on the pathogenesis of infectious diseases. The focus will be on diseases of worldwide importance, including tuberculosis, malaria, leishmaniasis, hepatitis C, and AIDS. The training program will utilize the resources of Weill Medical College of Cornell University (W. Johnson, E. Cesarman, K. Deitsch, S. Ehrt, L. Golightly, J. Ho, C. Nathan, D. Schnappinger, T. Templeton), the Rockefeller University (D. Ho, C. Rice, R. Steinman), and the Aaron Diamond AIDS Research Center (D. Ho). The program's senior faculty are funded scientists, committed to research and training. Six new potential mentors have been included - all with independent NIH research support. The training faculty has a long history of successful collaboration in research and training of international biomedical scientists through NIH Fogarty programs and have applied that experience to the training of US physician-scientists. During the current funding period (1999-2003), 10 trainees have been appointed--four have received and two have submitted NIH "K" awards or research supplements. The subject areas for these awards are KSHV-HHV8, HIV pathogenesis, HIV-TB coinfection, HIV vaccine development, leishmania pathogenesis and M. tuberculosis-NO interaction. In each of these awards, the primary T32 mentor continues as the K award mentor. Two former trainees are conducting research and training on HIV vaccines and bioterrorism. The two most recent trainees are in the process of defining their research projects (HIV-TB interaction and HIVhepatitis C coinfection). There have been three minority trainees (2 African-American, 1 Hispanic) and three female trainees. The program will continue to recruit physicians who have completed their clinical training (medicine, pediatrics, pathology) and are seeking academic investigative careers. The training faculty share the view that the physician-scientist is truly an endangered species. This training grant will provide young physicians with an opportunity to make the transition from their clinical training to the laboratory. The research training will be for 2-3 years with five fellows each year. Trainees will have the opportunity to work with outstanding mentors in Haiti (D. Fitzgerald, J. Pape) and in Brazil (E. Carvalho and A. Ko), if it is relevant to the US laboratory research. The research in Haiti and Brazil is focused on HIV natural history and transmission studies, opportunistic infections (leishmaniasis, tuberculosis), epidemiology, immunopathology, and interventions (behavioral, drug, vaccine).