HEALIH EFFECTS AND GEOCHEMISTRY OF ARSENIC AND LEAD

本提案是根据RFA ES-99-001《超级基金有害物质基础研究计划》提出的。土壤和饮用水中砷和铅的污染与重大的公共卫生、补救和环境政策问题有关。在大多数超级基金站点的土壤或水中发现了铅，而铅是一种土壤污染物，约为300。这项建议旨在获得关于土壤铅在人类体内的生物有效性，以及美国四个超级基金地点(两个铅污染和两个砷污染)的生物有效性和/或地球化学方面的新知识，并培训多学科的博士后和博士后学生。它还包括孟加拉国饮用水中砷的流行病学和地球化学研究，重点是砷暴露的致癌、生殖和儿童影响。我们还致力于制定饮用水废水中砷的实用补救策略。该建议包括四个生物医学研究项目：1)土壤中铅和砷在人类中的生物有效性；2)砷在哺乳动物细胞中的遗传毒性机制；3)孟加拉国环境砷中毒的队列研究；4)环境砷、妊娠和儿童健康。生物医学研究与三个非生物医学项目的研究直接相关：5)AS动员和孟加拉国地下水；6)在北非和缅因州的As重新分布；以及7)对地下水中As的浓缩进行评估和修复。这些研究项目得到了三个研究支持核心实验室的支持：8)痕量金属；9)地球化学；10)水文学行政核心，包括一个信息传播计划和一个政府联络与外联计划。最后，一个培训核心协调多学科教育和博士后和博士后学员之间的互动，并由这项提案以及其他培训赠款提供支助。

This proposal is submitted in response to RFA ES-99-001, entitled with Superfund Hazardous Substances Basic Research Program. The contamination of soils and drinking water with As and Pb are associated with major public health, remedial, and environmental policy problems. As is found in soil or water at the majority of Superfund sites while Pb is a soil-borne contaminant of concern at approximately 300. This proposal seeks to obtain new knowledge, and train multi-disciplinary pre- and post-doctoral students, concerning the bioavailability of soil Pb in humans, and the bioavailability and/or geochemistry at four Superfund sites in the U.S., two contaminated with Pb and two with As. It also encompasses epidemiologic and geochemistry studies of As in drinking water in Bangladesh which focus on carcinogenic, reproductive and childhood effects of As exposure. We also devote resources to the development of practical remediation strategies for As in wastewater in drinking water. The proposal includes four biomedical research projects: 1) Bioavailability of Soil Pb and As in Humans; 2) Genotoxic Mechanisms of As in Mammalian Cells; 3) A Cohort Study of Aresnicosis in Bangladesh; 4) Environmental As, Pregnancy, and Children's Health. The biomedical research is directly related to that which occurs in three non- biomedical projects: 5) As Mobilization and Bangladesh Groundwater; 6) Redistribution of As at Sites in NF and Maine; and 7) Assessment and Remediation for as Enrichments in Groundwater. The research projects are supported by three Research Support Core Labs: 8) Trace Metals; 9) Geochemistry; and 10) Hydrology An Administrative Core includes an Information Dissemination Program and a Government Liaison & Outreach Program. Finally, a Training Core coordinates multi- disciplinary education and interaction among pre- and post-doctoral trainees support by this proposal as well as other training grant.