CORE-- FACILITY FOR AGED RODENTS

CFAR是老年啮齿动物的核心设施，自1989年成立以来一直是密歇根大学克劳德·佩珀中心的主要特色。CFAR将继续通过四个具体目标来满足胡椒中心调查人员的需求。(1)CFAR将为所有OAIC调查人员提供建议，从学生到教师，在使用啮齿动物研究衰老的生物学及其在晚年疾病中的作用。(2)CFAR将支持专门的小鼠群体，特别适合研究衰老生物学及其与老年疾病的关系。这些包括（a）UM-HET 3原种的遗传异质小鼠;（B）热量限制的UM-HET 3小鼠;和（c）携带Pitl dw突变的长寿斯内尔侏儒（dw/dw）原种的小鼠。来自这些殖民地的小鼠将提供给从事PESC和RCDC研究项目的教职员工，以及希望 在NIA其他资金来源的支持下，开展小鼠衰老的试点研究。(3)CFAR基金将支持为特定目的开发新的动物模型。在第一年，这些将包括一个新的四元交叉适合研究晚年听力损失，和CAG重复基因敲入小鼠研究年龄依赖性运动神经元疾病的时间。(4)透过核心发展计划，培育新的啮齿动物研究计划。在第一年，将支持两个这样的项目，一个是开发仪器，用于评估平衡和前庭功能的年龄依赖性变化，另一个是使用热量限制和侏儒小鼠来评估衰老和抗衰老干预在皮肤细胞增殖和促肿瘤转化中的作用。CFAR主任还将在帮助开发和设计利用啮齿动物模型的RCDC和PESC项目方面发挥作用。

CFAR, the Core Facility for Aged Rodents, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR will continue to serve the needs of Pepper Center investigators through four Specific Aims. (1) CFAR will provide advice to all OAIC investigators, from student through faculty levels, in the use of rodents for research into the biology of aging and its role in late life disease. (2) CFAR will support specialized colonies of mice particularly well suited for research on the biology of aging and its relationship to late-life disease. These include (a) genetically heterogeneous mice of the UM-HET3 stock; (b) calorically restricted UM-HET3 mice; and (c) mice of the long-lived Snell dwarf (dw/dw) stock, carrying the Pitl dw mutation. Mice from these colonies will be provided to faculty members working on PESC and RCDC research projects, as well as to Geriatrics Center faculty members who wish to conduct pilot studies on mouse aging supported by other sources of NIA funds. (3) CFAR funds will support the development of new animal models for specific purposes. In the first year, these will include a new fourway cross suitable for studies of late-life hearing loss, and a CAG-repeat knock-in mouse to study the timing of age-dependent motor neuron disease. (4) To nurture new rodent-based research initiatives through Core Development Projects. In the first year two such projects will be supported, one to develop instrumentation for assessment of age-dependent changes in balance and vestibular function, and the other to use calorically restricted and dwarf mice to evaluate the role of aging and anti-aging interventions in skin cell proliferation and pro-neoplastic transformation. The CFAR director will also play a role in helping to develop and design RCDC and PESC projects that make use of rodent models.