Evaluating the genetic contribution to rheumatic heart disease pathogenesis in Australian Aboriginal and Torres Strait Islander communities

风湿性心脏病在澳大利亚土著人中非常普遍，并导致早期心脏病。尽管经过数十年的研究，但其发生的潜在遗传机制尚未得到很好的理解。我们正在进行一项遗传研究，以更好地了解为什么有些人易患RHD，而另一些人则不然。这项研究将涉及土著居民的大量领导和协商，并将成为在土著居民中进行遗传研究的典范。

Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.