Sleep during the peri-menopause in a multi-ethnic cohort

描述：（由申请人提供）这项互动研究项目资助 （IRPG）将描述绝经特征之间的关系 在430名女性的样本中进行睡眠测试：200名白人，150名非洲裔美国人， 80个中国人。 虽然睡眠中断，失眠和睡眠的发生率 中年妇女呼吸紊乱增加，对这一点知之甚少。 更年期与睡眠的关系 血管痉挛症状的影响 激素替代疗法表明睡眠更年期 关系不仅仅是年龄的函数。 更好地了解 中年妇女睡眠障碍的原因是重要的，考虑到影响 睡眠对身心健康的影响。 睡眠障碍与 一系列负面的健康结果，包括生产力的损失， 生活质量，精神病发病率，免疫抑制， 对疾病的脆弱性。 本研究小组的研究目的是：1） 在一个大的，多种族的中年样本中描述睡眠障碍的特征 妇女; 2）表征绝经特征之间的关系， 睡眠障碍; 3）评估相关心理生物学的影响 睡眠-绝经关系的因素; 4）建立基线数据 未来的纵向研究。 正在进行的七个研究中心中的四个 全国妇女健康研究（SWAN）将合作招募一名 来自SWAN队列的绝经前和围绝经期妇女的样本。 一旦入组 在睡眠研究中，参与者将在新的睡眠研究开始时开始方案。 月经周期 将进行动态多导睡眠描记术， 参与者在方案的第1-3天回家。 睡眠日记，活动记录仪， 将收集血管痉挛症状数据的事件监测记录 在整个周期中。 数据还将包括五年的核心SWAN研究 绝经期特征（出血模式，血管炎症状， 激素水平）和相关的心理生物学因素。回归技术 将被用来模拟更年期特征，睡眠， 以及相关的心理生物学因素。 匹兹堡研究中心将培训研究 睡眠监测设备的使用人员，并将负责 处理、评分和存档所有睡眠数据。所有睡眠研究数据，如 以及来自核心SWAN研究的相关数据，将被合并和分析， 密歇根的网站 芝加哥和加州大学戴维斯分校的PI将共同主持睡眠研究 指导委员会。

DESCRIPTION: (provided by applicant) This interactive Research Project Grant (IRPG) will characterize the relationship between menopausal characteristics and sleep in a sample of 430 women: 200 Caucasian, 150 African-American, and 80 Chinese. Although sleep disruptions, insomnia and the incidence of sleep disordered breathing increase in mid-life women, little is known about the relationship between menopause and sleep. The impact of vasomotor symptoms and hormone replacement therapy on sleep suggests that the sleep-menopause relationship is not merely a function of age. A greater understanding of the causes of sleep disturbances in mid-life women is important, given the impact of sleep on mental and physical health. Sleep disturbances are associated with a host of negative health outcomes including losses in productivity and quality of life, psychiatric morbidity, immunosuppression, and increased vulnerability to illness and disease. The study aims of this IRPG are to: 1) characterize sleep disturbances in a large, multi-ethnic sample of mid-life women; 2) characterize relationships among menopausal characteristics and sleep disturbances; 3) evaluate the influence of relevant psychobiological factors on the sleep-menopause relationship; and 4) establish baseline data for a future longitudinal study. Four of seven study sites from the ongoing Study of Women s Health Across the Nation (SWAN) will collaborate to recruit a sample of pre- and peri-menopausal women from the SWAN cohort. Once enrolled in the Sleep Study, participants will begin the protocol at the start of a new menstrual cycle. Ambulatory polysomnography will be conducted in participants homes during days 1-3 of the protocol. Sleep diary, actigraphy, and event monitor recordings of vasomotor symptom data will be collected throughout the cycle. Data will also include five years of Core SWAN study data on menopausal characteristics (bleeding patterns, vasomotor symptoms, hormone levels) and related psychobiological factors. Regression techniques will be used to model relationships among menopausal characteristics, sleep, and related psychobiological factors. The Pittsburgh site will train study personnel in the use of sleep monitoring equipment and will be responsible for processing, scoring, and archiving all sleep data. All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC Davis PIs will co-chair the Sleep Study Steering Committee.