Host-pathogen interaction in Vibrio cholerae infection

描述（由申请人提供）：本申请详细介绍了一个为期四年的细菌致病机理国际研究职业发展计划。该计划将在Stephen B博士的合作指导下进行。Calderwood，马萨诸塞州总医院传染病科，波士顿，马萨诸塞州和Firdausi Qadri博士，实验室科学科，ICDDR，B：卫生和人口研究中心，达卡，孟加拉国。该候选人接受过传染病方面的培训，长期目标是在细菌发病机理和国际卫生领域从事独立的研究工作。培训计划将包括免疫学、遗传学和研究伦理学课程。研究部分将侧重于霍乱弧菌感染中的宿主-病原体相互作用。本研究的三个具体目标是：（1）利用高通量基因微阵列技术鉴定霍乱弧菌的毒力因子;（2）鉴定霍乱弧菌保护性免疫应答中重要的免疫显性蛋白;（3）研究影响霍乱弧菌易感性的宿主遗传因素。导师和咨询委员会将监督申请人的进展和研究。该计划将使候选人获得技能，知识和经验，成为一个独立的生物医学研究人员专注于全球健康挑战。

DESCRIPTION (provided by applicant): This application details a four-year international research career development program in bacterial pathogenesis. The program will be conducted under the collaborative mentorship of Dr. Stephen B. Calderwood, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts and Dr. Firdausi Qadri, Laboratory Sciences Division, ICDDR,B: Centre for Health and Population Research, Dhaka, Bangladesh. The candidate is trained in Infectious Diseases and has the long-term goal of pursuing an independent research career in the field of bacterial pathogenesis and international health. The training program will include courses in immunology, genetics and research ethics. The research component will focus on host-pathogen interactions in Vibrio cholerae infection. Three specific aims will be addressed: (1) to use high-throughput gene microarray techniques to identify virulence factors of V. cholerae; (2) to characterize immunodominant proteins important in the protective immune response to V. cholerae; and (3) to study host genetic factors which influence susceptibility to V. cholerae. The mentors and an advisory committee will oversee the applicant's progress and research. The program will allow the candidate to obtain the skills, knowledge and experience to become an independent biomedical researcher focused on global health challenges.