Core--Exposure Assessment

描述（由申请人提供）：新中心的暴露评估核心将专注于分析化学需求和基于生理学的毒物动力学（PBTK）建模。在第一个中心（1998-2003）期间，适当收集和处理现场样本（房屋灰尘、汽车灰尘和尿液）进行农药分析对CIP项目至关重要。由于实地研究人员现已接受培训，并已培训其他人员进行这些程序，新中心的重点将是为社区参与性研究项目和农药途径项目收集的实地样本提供分析支助。在中心的第一个资助周期中，动力学建模也证明了对分子机制和遗传易感性信息的理解和翻译是非常宝贵的。因此，这些领域已列为新中心的优先事项。华盛顿大学儿童环境健康风险研究中心的接触评估核心有以下具体目标：

Description (provided by applicant): The Exposure Assessment Core in the new Center will be focused on the analytical chemistry needs and physiologically based toxicokinetic (PBTK) modeling. During the first Center (1998-2003), appropriate collection and handling of field samples (house dust, car dust, and urine) for pesticide analysis was critical for the CIP project. Since field researchers have now been trained and have trained others in these procedures, the emphasis in the new Center will be on providing analytical support for field samples collected by the Community Based Participatory Research Project and the Pesticide Pathways Projects. In first funding cycle of the Center, kinetic modeling also proved invaluable for understanding and translating information on molecular mechanisms and genetic susceptibility. Thus, these areas have been prioritized for the new Center. The Exposure Assessment Core of the University of Washington Center for Child Environmental Health Risks Research has had the following specific aims: Specific aim 1: Provide analytical chemical support to the Community-Based Participatory Research (CBPR) Project and the Pesticide Pathways Project Analyses of house dust, vehicle dust, and urine from adults and children will include organophosphate (OPs) pesticides and metabolites from over 200 households. Specific aim 2: Provide assistance with the interpretation of exposure data to the Community-Based Participatory Research (CBPR) Project and the Pesticide Pathways Project. Interpretation of the results from the house dust, vehicle dust, and urinary analyses is not a straightforward process due to the complex relationship between environmental samples and urinary metabolites. Specific aim 3: Coordinate mechanistic modeling of exposure and dose among all Center projects to be linked with dynamic modeling performed by the Risk Characterization Core. Stochastic models will be generated to explore links between measured environmental pesticide levels and biomonitoring results and ultimately to biological effects. This will require mathematical representation of human behaviors, chemical transfer and absorption processes, and the pharmacokinetics of metabolism and excretion. Exposure and pharmacokinetic models with then be linked with biologically based dose response models to better explore exposure response relationships.