Gordon Conference "Motile and Contractile Systems" 2005

描述(由申请者提供)：申请部分资助将于2005年7月10日至7月15日在新罕布夏州科尔比-索耶学院举行的2005年戈登运动和收缩系统研究会议。这次会议的目的是鼓励在细胞骨架研究前沿工作的科学家社区内的想法和信息的交流，该领域长期以来一直被认为是理解基本生物过程的关键。细胞骨架元素是真核生物生命所必需的，对细胞运动、细胞信号传递、膜运输、细胞分裂、细胞极性和多细胞生物体的发育起着重要的作用。肌动蛋白、微管和马达对创伤愈合、病原体-细胞相互作用、细胞免疫和胚胎发育等许多正常生理功能都具有重要作用。此外，细胞骨架缺陷是许多人类病理性疾病的基础，包括肌肉骨骼和神经退行性疾病、个体发育、呼吸系统疾病、不孕不育以及先天性失明和耳聋。2005年的会议将集中讨论活细胞中细胞骨架元素的动力学，以及这些复合体在细胞运动、膜结合的囊泡和mRNAs的细胞内运输、伤口愈合、染色体分离和细胞分裂以及发育中的组织形态形成中的功能。一个特别的会议将专门讨论编码细胞骨架蛋白的基因突变引起的病理情况。由于其广度和跨学科性质，移动和收缩的系统戈登会议继续在该领域发挥开创性的作用，尽管次级专业会议激增。会议将由Joel Rosenbaum博士作主旨演讲，他将讨论鞭毛内运输的生物学作用以及由其缺陷引起的病理情况。大约60名杰出的研究科学家将在八个讲座/讨论环节中作正式陈述。这些报告中约有三分之一将从提交的摘要中挑选出来，以鼓励杰出的新研究人员、博士后和学生参与。不做口头发言的与会者将被鼓励以海报的形式展示他们最近的作品。

DESCRIPTION (provided by applicant): Partial support is requested for the 2005 Gordon Research Conference on Motile and Contractile Systems to be held July 10- July 15, 2005 at Colby-Sawyer College in New Hampshire. The purpose of this conference is to encourage the transfer of ideas and information within the community of scientists who work at the forefront of cytoskeletal research, an area that has long been recognized as critical for understanding fundamental biological processes. Cytoskeletal elements are essential for life in eukaryotes, making central contributions to cell motility, cell signaling, membrane trafficking, cell division, cell polarity, and the development of multicellular organisms. Actin, microtubules and motors are important for many normal physiological functions including wound healing, pathogen-cell interactions, celli-mediated immunity and embryogenesis. Moreover, cytoskeletal defects underlay many pathological human conditions including musculoskeletal and neurodegenerative diseases, ontogenesis, respiratory diseases, infertility, and congenital blindness and deafness. The 2005 conference will focus on dynamics of cytoskeletal elements in living cells, and the functions of these complexes in cell locomotion, intracellular transport of membrane-bounded vesicles and mRNAs, wound healing, chromosome segregation and cell division, and tissue morphogenesis in development. A special session will be devoted to pathological conditions caused by mutations in genes encoding cytoskeletal proteins. Because of its breadth and interdisciplinary nature, the Motile and Contractile Systems Gordon Conference has continued to play a seminal role in the field, despite the proliferation of subspecialty meetings. The conference will feature a Keynote Lecture by Dr. Joel Rosenbaum who will discuss the biological role of intraflagellar transport and pathological conditions caused by its deficiency. Approximately 60 outstanding research scientists will make formal presentations in eight lecture/discussion sessions. About one-third of these presentations will be selected from the submitted abstracts to encourage participation by outstanding new investigators, postdocs and students. Conferees who do not make oral contributions will be encouraged to present their recent work in a poster format.