Gordon Conference "Motile and Contractile Systems" 2005

描述（由申请人提供）：为将于2005年7月10日至15日在新罕布什尔州科尔比索耶学院举行的2005年戈登移动和收缩系统研究会议提供部分支持。本次会议的目的是鼓励在细胞骨架研究前沿工作的科学家社区内交流思想和信息，这一领域长期以来被认为是理解基本生物过程的关键。细胞骨架元件对真核生物的生命至关重要，在细胞运动、细胞信号传导、膜运输、细胞分裂、细胞极性和多细胞生物的发育中起着重要作用。肌动蛋白、微管和马达对许多正常的生理功能都很重要，包括伤口愈合、病原体-细胞相互作用、细胞介导的免疫和胚胎发生。此外，细胞骨骼缺陷是许多病理性人类疾病的基础，包括肌肉骨骼和神经退行性疾病、个体发生、呼吸系统疾病、不孕症、先天性失明和耳聋。2005年的会议将集中讨论活细胞中细胞骨架元件的动力学，以及这些复合物在细胞运动、膜结合囊泡和mrna的细胞内运输、伤口愈合、染色体分离和细胞分裂以及发育中的组织形态发生中的功能。特别会议将专门讨论由编码细胞骨架蛋白的基因突变引起的病理状况。由于其广度和跨学科的性质，尽管次级专业会议激增，但运动和收缩系统戈登会议继续在该领域发挥着开创性的作用。会议将以Joel Rosenbaum博士的主题演讲为特色，他将讨论鞭毛内转运的生物学作用和由其缺乏引起的病理状况。大约60位杰出的研究科学家将在8个讲座/讨论环节中进行正式报告。大约三分之一的报告将从提交的摘要中选出，以鼓励优秀的新研究者、博士后和学生参与。不作口头贡献的与会者将被鼓励以海报的形式展示他们最近的工作。

DESCRIPTION (provided by applicant): Partial support is requested for the 2005 Gordon Research Conference on Motile and Contractile Systems to be held July 10- July 15, 2005 at Colby-Sawyer College in New Hampshire. The purpose of this conference is to encourage the transfer of ideas and information within the community of scientists who work at the forefront of cytoskeletal research, an area that has long been recognized as critical for understanding fundamental biological processes. Cytoskeletal elements are essential for life in eukaryotes, making central contributions to cell motility, cell signaling, membrane trafficking, cell division, cell polarity, and the development of multicellular organisms. Actin, microtubules and motors are important for many normal physiological functions including wound healing, pathogen-cell interactions, celli-mediated immunity and embryogenesis. Moreover, cytoskeletal defects underlay many pathological human conditions including musculoskeletal and neurodegenerative diseases, ontogenesis, respiratory diseases, infertility, and congenital blindness and deafness. The 2005 conference will focus on dynamics of cytoskeletal elements in living cells, and the functions of these complexes in cell locomotion, intracellular transport of membrane-bounded vesicles and mRNAs, wound healing, chromosome segregation and cell division, and tissue morphogenesis in development. A special session will be devoted to pathological conditions caused by mutations in genes encoding cytoskeletal proteins. Because of its breadth and interdisciplinary nature, the Motile and Contractile Systems Gordon Conference has continued to play a seminal role in the field, despite the proliferation of subspecialty meetings. The conference will feature a Keynote Lecture by Dr. Joel Rosenbaum who will discuss the biological role of intraflagellar transport and pathological conditions caused by its deficiency. Approximately 60 outstanding research scientists will make formal presentations in eight lecture/discussion sessions. About one-third of these presentations will be selected from the submitted abstracts to encourage participation by outstanding new investigators, postdocs and students. Conferees who do not make oral contributions will be encouraged to present their recent work in a poster format.