Transport studies of particle beam biological effects

描述（由申请人提供）：本研究的目的是确定目前在质子放疗中使用的放射生物学有效性（RBE）值是否准确，并在整个辐照体积中得到充分理解，以提供最有效的治疗。如果这些值被低估，这意味着接受质子治疗的患者可能接受的剂量高于肿瘤区域以及目标区域周围健康组织所需的剂量。这些值可能受到二次粒子的产生以及质子相互作用产生的反冲核的影响。为了确定这一点，将使用独特的核数据库和中间能量核建模代码进行蒙特卡罗模拟，并对几种临床相关情况进行测试。除了确定质子RBE和空间变化外，我们还将研究离子（如12C）的RBE，这些离子在放射治疗中具有几个优势。近年来，人们对使用这类离子进行治疗的兴趣有所增加。

DESCRIPTION (provided by applicant): The objective of this research is to determine if the radiobiological effectiveness (RBE) values used presently in proton radiotherapy are accurate and well understood throughout the irradiated volume to provide the most efficacious treatment. If these values are underestimated this means that patients treated with protons could be receiving higher doses than required in the tumor area as well as in the healthy tissue surrounding the target area. These values could be affected by the production of secondary particles as well as recoil nuclei due to proton interactions. In order to determine this, Monte Carlo simulations using unique nuclear data libraries and intermediate energy nuclear modeling codes will be performed and several circumstances of clinical relevance tested. In addition to determining the proton RBE and spatial variation, we will investigate the RBE of ions such as 12C that present several advantages for radiotherapy. In recent years, the interest in using such kinds of ions for therapy have increased.