VASCULAR BIOLOGY IN CANCER

描述(由申请人提供)：博士后研究员在六个独立实验室之一的教务主任的监督下，在基础和适用的血管生物学的调查性发现方面提供直接的研究经验、责任和培训。人们正在探索内皮细胞、分子细胞生物学和相关的分子和系统，以描绘与肿瘤环境相关的血管发育所赋予的基因表达模式。其中包括对可能与癌症血管生物学有关的基因表达模式和细胞信号通路的调查。受训人员开展的研究包括但不限于：发现肿瘤体内血管内皮细胞基因表达的新模式、血管生成的控制、影响内皮细胞生物学的细胞信号事件、肿瘤微血管环境中调节的血栓形成和炎症级联反应、抑制肿瘤相关血管生成的蛋白质及其衍生分子的设计，以及尝试开发针对肿瘤环境的血管消融分子。受训者与他们的全职研究人员导师保持着密切的联系。每周一次的研讨会和数据审查是由每个教员和他们的小组进行的。医学博士、博士和医学博士/博士候选人被招募，并为独立的调查职业做好准备。

DESCRIPTION (provided by applicant): Postdoctoral research fellows are provided direct research experience, responsibility, and training in conduct of investigative discovery of fundamental and applicable vascular biology under supervision of a faculty head of one of the six independent laboratory units. Endothelial cell molecular cell biology and related molecules and systems are being explored to delineate patterns of gene expression imparted by vascular development when in association with the tumor environment. These include survey of gene expression patterns and cell signaling pathways that may be implicated in the vascular biology of cancer. Investigations conducted by trainees include, but are not limited to, discovery of novel patterns of gene expression by the vascular endothelium in vivo in tumors, control of angiogenesis, cell signaling events influencing endothelial cell biology, the thrombogenic and inflammatory cascades as regulated in the tumor microvasculature environment, the design of proteins and derivative molecules to inhibit tumor associated angiogenesis as well as attempts to development vascular ablative molecules selective for the tumor environment. Trainees are in immediate close association with their mentors who are full-time research faculty. Weekly seminars and review of data are conducted by each of the faculty members with their group. M.D., Ph.D. and M.D./Ph.D. candidates are recruited and prepared for an independent investigative career.