SYNTHESIS AND SYNTHETIC UTILITY OF 1-ACYLDIHYDROPYRIDINE

描述：（主要研究者摘要）本研究的目的是 本论文的工作是发展新的1-酰基二氢吡啶的合成方法 和二氢吡啶酮，并研究它们作为合成中间体的用途。 具体目标包括： 1.继续研究不对称合成和反应 1-酰基-2-烷基1，2-二氢吡啶和2，3-二氢-4-吡啶酮。 2 .完成了链唑啉的对映选择性全合成， cannabisativine和allopumiliotoxin。 3 .探索了一种对映选择性合成各种手性化合物的通用方法， 石松生物碱通过手性二氢吡啶中间体合成。 所提出的方法将用于合成具有以下结构的化合物： 广泛的生物学特性，即神经安定，抗高血压， 抗炎、抗癌、抗AIDS和抗惊厥活性。

DESCRIPTION: (Principal Investigator's Abstract) The objective of this proposed work is to develop methods for the synthesis of novel 1-acyldihydropyridines and dihydropyridones and to study their utility as synthetic intermediates. Specific aims include: 1. To continue studying the asymmetric synthesis and reactions of 1-acyl-2-alkyl 1,2-dihydropyridines and 2,3-dihydro-4-pyridones. 2 .To complete the enantioselective total syntheses of streptazolin, cannabisativine and allopumiliotoxin. 3 .To investigate a general approach to enantioselective synthesis of various lycopodium alkaloids via chiral dihydropyridine intermediates. The proposed methodology will be useful for the synthesis of compounds having a broad range of biological properties, i.e. neuroleptic, antihypertensive, anti-inflammatory, anticancer, anti-AIDS, and anticonvulsant activities.