CORE--BIOSTATISTICS AND COMPUTATIONAL BIOLOGY

描述(申请人提供)：生物统计学和生物统计的主要职责 计算生物学(BCB)研究团队将通过以下方式参与CFAR研究工作 在新项目的发展阶段和编写赠款提案期间提供实验设计和数据分析咨询，并就信息学和数学/统计建模的创新办法与调查人员合作。支持的领域将包括临床生物统计学和计算生物学，包括基因表达以及核酸和蛋白质序列分析的所有方面。在与杜克大学计算免疫学实验室的合作下，BCB核心还将支持病毒和免疫动力学的方法学开发和数学建模。与CFAR调查人员的互动将有两种模式。在第一种情况下，新的创新项目将被视为合作努力，不向客户收费。预计BCB将作为这项新工作产生的赠款和合同的合作者获得补偿。此外，BCB可能获得提交相关方法工作申请的机会。在第二种模式下，为统计和/或计算生物学工作提供资金的正在进行的项目以及行业赞助的项目可以签约。 在收费的基础上与BCB合作。BCB核心致力于建立和维护与CFAR调查员和其他核心的轻松沟通。BCB主任托马斯·B·开普勒博士在免疫学(杜克大学免疫学系二次任职)以及计算生物学和统计学方面拥有专业知识，这些都是他的主要研究领域。核心小组将接受培训，了解科学和医学以及表达它们的语言。

DESCRIPTION (provided by applicant): The primary responsibilities of the Biostatistics and Computational Biology (BCB) research team will be to participate in the CFAR research effort by supplying experimental design and data-analytical consulting during the developmental stages of new projects and in the preparation of grant proposals and to work with investigators on innovative approaches to informatics and mathematical/statistical modeling. The areas supported will include clinical biostatistics and computational biology, including gene expression and all aspects of nucleic acid and protein sequence analysis. In collaboration with Duke University Laboratory of Computational Immunology, the BCB core will also support methodological development and mathematical modeling of viral and immune dynamics. There will be two modes of interaction with the CFAR investigators. Under the first, new innovative projects will be treated as collaborative endeavors with no charge-back to the client. The expectation is that compensation will accrue to the BCB as collaborators on grants and contracts arising from this new work. Furthermore, the BCB may gain the opportunity to submit applications for related methodological work. Under the second model, ongoing projects with funding for statistical and/or computational biological work as well as industry-sponsored projects can contract with the BCB on a for-fee basis. The BCB core is devoted to the establishment and maintenance of easy communication with the CFAR investigators and the other cores. The BCB director, Dr. Thomas B. Kepler, has expertise in immunology (and a secondary appointment in the Duke Department of Immunology) as well as computational biology and statistics, which are his primary research fields. The core group will be trained to understand the science and medicine and the language in which they are expressed.