Spatial Information Management Resources for Human Brain

描述(申请人提供)：神经学家和临床医生需要强大的计算机化数据和图像管理资源，以应对日益增长的关于大脑的新信息浪潮。这种资源必须是全面的、可获取的，并能够与其他计算机化系统直接通信，而不需要人工干预。经典的神经解剖学标志为整合关于大脑的新的和现有的信息提供了一个基本的参照系。BrainInfo是一个Web资源，其中的信息通过一个全面的神经解剖命名法进行索引。神经命名法与国家医学图书馆的统一医学语言系统完全集成在一起。它包括人类和非人类灵长类大脑的术语。该术语的适当部分已被纳入神经解剖学定义系统，该系统通过参考非人类灵长类动物大脑的图谱来说明结构概念。我们建议创建一个人脑的三维计算机化图谱，并将这一定义系统扩展到人脑，建立机制，使Braininfo网站的访问者可以将数据映射到Web上的大脑图谱，并在BrainInfo和关于人类大脑功能的两个最广泛的网络数据源之间建立兼容性和互操作性。BrainInfo和NeuroNames的资源目标是加速获取和分发关于大脑的现有和新的科学知识。这将通过应用数字通信技术，以适应神经科学家、临床医生和神经解剖学学生的知识结构和直观搜索策略的方式，通过网络实现关于大脑的即时信息交流。(http://braininfo.rprc.washington.edu))

DESCRIPTION (provided by applicant): Neuroscientists and clinicians need powerful computerized data and image management resources to deal with the rising tide of new information about the brain. Such resources need to be comprehensive, accessible and capable of communicating directly with other computerized systems without the need for human intervention. Classical neuroanatomical landmarks provide an essential frame of reference for integrating new and existing information about the brain. Braininfo is a Web resource in which information is indexed by a comprehensive neuroanatomical nomenclature. The nomenclature, NeuroNames, is fully integrated with the Unified Medical Language System of the National Library of Medicine. It includes terminology for both the human and the nonhuman primate brain. Appropriate parts of the nomenclature have been incorporated into a system of neuroanatomical definitions that illustrates structural concepts by reference to an atlas of the nonhuman primate brain. We propose to create a 3-dimensional computerized atlas of the human brain and to extend this definitional system to the human brain, to establish mechanisms whereby visitors to the Brainlnfo website can map data into brain atlases on the Web, and to establish compatibility and interoperability between Brainlnfo and two of the most extensive web-based sources of data on human brain function. The resource objective of Brainlnfo and NeuroNames is to accelerate the acquisition and distribution of existing and new scientific knowledge about the brain. This will be accomplished by applying digital communications technology to enable immediate communication of information about the brain via the Web in a manner tailored to the knowledge structure and intuitive search strategies of neuroscientists, clinicians, and students of neuroanatomy. (http://braininfo.rprc.washington.edu)