Assessment Of Multiple Analytes In Women With Osteoporos

绝经前和绝经后妇女的骨丢失是一种严重的临床状况，影响相当大比例的公众。抑郁症是一种复合性疾病，已被证明会加重导致骨质流失的途径，并暗示身心联系。在NIH临床中心进行的POWER研究旨在研究绝经前妇女抑郁症和骨质疏松症严重程度的相互作用。DBEPS超微量分析免疫化学资源已着手开发一组分析技术（回收免疫亲和层析[RIC];免疫亲和微阵列;免疫亲和毛细管电泳[ICE]），以研究许多可能参与骨质疏松症和抑郁症之间联系的不同全身途径。到目前为止，正常和抑郁年龄匹配的女性队列已被招募到研究中。该研究正在进行中，尽管出现了许多潜在的有趣结果，但队列是双盲的，直到招募阶段结束才揭盲。

Bone loss in women pre- and post-menopause is a serious clinical condition affecting a reasonably large proportion of the general public. Depression is a compounding condition that has been shown to accentuate pathways leading to bone loss and suggesting a mind-body connection. The POWER study conducted at the NIH Clinical Center is designed to study the interactions of depression and severity of osteoporosis in pre-menopausal women. The DBEPS Ultramicro Analytical Immunochemistry Resource has undertaken to develop a panel of analytical techniques (recycling immunoaffinity chromatography [RIC]; immunoaffinity microarrays; immunoaffinity capillary electrophoresis [ICE]) to study a number of different systemic pathways that possibly may be involved in the connection between osteoporosis and depression. To date cohorts of both normal and depressed age-matched women have been recruited into the study. The study is ongoing, and although many potentially interesting findings have arisen, the cohorts are double-blinded and the codes will not be broken until the end of the recruitment phase.