Crystallographic Studies of Chemokines, Chemokine Recept

我们的部分正在研究通过趋化作用的细胞间信号的结构基础，以及趋化因子和防御素在病毒感染过程中的作用。我们还对防御素和趋化因子的结构与它们的抗菌和趋化特性之间的关系感兴趣。我们还研究了人L-天冬酰胺酶和植物型天冬酰胺酶的酶机制和特异性，尿激酶型纤溶酶原激活剂复合体的结构及其受体以及TLT-1。虽然我们在研究中主要使用X射线结晶学，但我们的研究技术扩展到生物化学和分子生物学。我们最近的努力集中在三个不同的领域：1)趋化因子和趋化因子受体，2)α和β-防御素，3)尿激酶型纤溶酶原激活剂及其受体的复合体，4)TLT-1

Our section is investigating the structural basis of intercellular signaling via chemotaxis and the role of chemokines and defensins in the process of viral infection. We are also interested in correlating the structures of defensins and chemokines with their antimicrobial and chemotactic properties. We are also studying the enzymatic mechanism and specificity of human L-asparaginase and plant-type asparaginases, structures of urokinase plasminogen activator complex with its receptor as wel as TREM-Like Transcript protein 1 (TLT-1). Although we primarily use X-ray crystallography in our studies, our research techniques extend into biochemistry and molecular biology. Our recent efforts have been concentrated inthree distinct areas: 1) chemokines and chemokine receptors, 2)alpha- and beta-defensins, 3) Complex of urokinase plasminogen activator and its receptor, 4) TLT-1