2005 (Oculomotor System Biology) Gordon Conference

描述（由申请人提供）：经过超过35年的行为和单一单位的研究清醒，行为动物，眼系统可以说是最好的理解骨骼运动控制系统。传统上，科学家们研究了五个眼神经子系统孤立。直到最近才开始推动全系统一体化。此外，该领域已经开始利用成像技术，非灵长类动物模型（小鼠，斑马鱼）和分子遗传学方法来产生健康和疾病中眼科系统的真正多学科观点。该提案要求支持召开一次会议，旨在将这一成熟领域的科学家和医生聚集在一起，重新审视眼科系统的不同组成部分如何相互作用，并促进跨学科研究的增加。会议的重点将放在五个主要的新兴主题上。首先，快速发展的眼眶和眼外肌生物学的概念需要重新检查和重新解释已知的神经信号和现有的系统模型。其次，眼动子系统不孤立地运作，会议将被构造为具有重要的新数据之间的相互作用扫视和聚散度系统和眼睛和头部运动系统。第三，最近的建模工作和体外实验提出了质疑，从而需要重新审查的公认的机制，从清醒的，行为动物的研究制定的感觉运动整合。第四，虽然对感觉运动相互作用的编码和这种编码的坐标框架进行了长期研究，但对多感觉相互作用和目标选择机制的研究已经达到了一个重要的新水平，这将在会议上得到强调。最后，利用分子遗传学和模式生物来理解眼功能和功能障碍的新策略正在发展，必须整合到眼生物学的传统观点中。因此，我们力求将不经常在同一地点的想法和调查人员聚集在一起。

DESCRIPTION (provided by applicant): After more than 35 years of behavioral and single unit studies in awake, behaving animals, the oculomotor system is arguably the best understood of the skeletomotor control systems. Traditionally, scientists have investigated the five oculomotor subsystems in isolation. Only recently has there been a push to pursue system-wide integration. Moreover, the field has begun to utilize imaging techniques, non-primate models (mouse, zebrafish), and molecular genetics approaches to generate a truly multidisciplinary view of the oculomotor system in health and disease. This proposal requests support for a conference designed to bring together scientists and physicians in this mature field to take a fresh look at how the diverse components of the oculomotor system interact and to stimulate increased interdisciplinary research. The emphasis of the conference will be upon five major emerging topics. First, rapidly evolving concepts of orbit and extraocular muscle biology require both re-examination and reinterpretation of known neural signals and existing system models. Second, oculomotor subsystems do not operate in isolation; the conference will be structured to feature important new data on the interactions between saccadic and vergence systems and between eye and head movement systems. Third, recent modeling efforts and in vitro experiments have questioned and thereby require re-examination of the accepted mechanisms of sensorimotor integration formulated from studies in awake, behaving animals. Fourth, while the coding of sensorimotor interactions and the coordinate frames for this coding have long been studied, research into the mechanisms of polysensory interactions and target selection has reached an important new level that will be highlighted by the conference. Finally, new strategies to understand oculomotor function and dysfunction using molecular genetics and model organisms are evolving and must be integrated into traditional views of oculomotor biology. Hence, we seek to bring together ideas and investigators that are not often at the same venue.