Xenbase: a Xenopus Model Organism Database

描述（由申请人提供）：对非洲爪蟾胚胎的研究证明了诱导相互作用在驱动脊椎动物模式形成、细胞规范和形态发生中的重要性。中胚层爪蟾的诱导和模式是所有脊椎动物系统中最容易理解的发育级联，在某些水平上可以与强大的无脊椎动物遗传系统（如果蝇和秀丽隐杆线虫）相媲美。随着发育生物学进入后基因组时代，非洲爪蟾系统丰富的历史和无与伦比的实验可操作性将为我们理解基因在调节胚胎发育中的作用做出巨大贡献。

DESCRIPTION (provided by applicant): Studies on the Xenopus embryo demonstrated the importance of inductive interactions that drive vertebrate pattern formation, cell specification and morphogenesis. The induction and patterning of the Xenopus mesoderm is the best understood developmental cascade in any vertebrate system and on some levels rivals those of the powerful invertebrate genetic systems such as Drosophila and C. elegans. As developmental biology moves into the post-genomic era the rich history and unparalleled experimental manipulability of the Xenopus system is poised to make enormous contributions to our understanding of the role genes play in regulating embryonic development. Despite the vast amount of data that has been published or is available in public databases, there is at present no model organism database dedicated to storing and interlinking Xenopus data. Over 400,000 Xenopus EST's are available, the Xenopus genome project has generated over 1.6 billion base pairs, over 500 whole mount sets of gene expression patterns are available, some 20,000 publications and an enormous amount of anatomical and histological data exists. Due to the lack of an anatomical ontology and an integrated database a vast amount of effort is currently required to search for required information and relational analysis, for example matching an EST to an expression pattern, is not currently possible. This project will implement a model organism database dedicated to storing, annotating and analyzing biological data on both Xenopus laevis and X. tropicalis. The development and application of standard nomenclatures and controlled vocabularies to Xenopus data will allow all of the different forms of information to be related to each other and vastly increase the power of computational analysis. In addition to providing a critical resource to the Xenopus community this database will also allow the wealth of data on gene function generated by Xenopus researchers to be used by those investigating other systems, especially those in which gene function is more difficult to analyze.