The role of microbial organisms in acute lung injury

这个应用程序是为了支持凯文博士的发展，使他成为一个 有成就的临床科学家和独立研究者。加里·汉宁哈克医生会假设 作为导师的责任，以确保职业发展计划的成功。该提案的重点是在人类肺损伤和脓毒症研究方面的深入研究经验。为了实现这一目标，Doerschug博士将继续接受人体研究设计和分析方面的正式培训，以及分析急性肺损伤和脓毒症患者标本的科学技术。Doerschug博士将完成这些领域的教学培训，包括流行病学，统计学，细胞生物学和微生物学课程。Doerschug博士的课程将最终获得转化生物医学研究硕士学位。研究指导将涉及积极开发和参与旨在确定急性肺损伤和脓毒症发病机制相关因素的研究。具体来说，Doerschug博士将重点关注循环微生物作为炎症刺激物的作用， 这些疾病的特征。最初的研究将包括鉴定SIRS患者的菌血症或真菌血症（脓毒症和急性肺损伤的常见风险因素），使用PCR检测以前无法检测到的微生物。此外，Doerschug博士将研究循环微生物与急性肺损伤发展之间的关系，重点关注患者的生理学和结局。一旦完成，这些初步研究将更准确地描述这些疾病中感染和炎症之间的关系。进一步的研究可以集中在修改宿主对这些感染的反应。在Doerschug博士的整个职业发展过程中，他将与临床研究、肺部医学和微生物学方面的学员进行交流。这种智力丰富的环境 将有助于促进Doerschug博士的职业发展，在整个获奖期间提供充分的批判性审查机会。导师和机构都高度致力于博士Doerschug的科学发展和学术成功。

This application is to support the development of Dr. Kevin Doerschug so that he will become an accomplished clinician-scientist and independent researcher. Dr. Gary Hunninghake will assume responsibility as mentor to ensure the success of the career development plan. The focus of the proposal is an intensive research experience in studies of human lung injury and sepsis. To achieve this, Dr. Doerschug will continue formal training in the design and analysis of human studies, as well as scientific techniques to analyze specimens from human patients with acute lung injury and sepsis. Dr. Doerschug will complete didactic training in these areas including classes in epidemiology, statistics, cell biology, and microbiology. Dr. Doerschug's classes will culminate in a Master's Degree in Translational Biomedical Research. The research mentorship will involve active development of and participation in studies designed to identify factors involved in the pathogenesis of acute lung injury and sepsis. Specifically, Dr. Doerschug will focus on the role of circulating microorganisms as the stimulus for the inflammation that characterizes these diseases. Initial studies will include identifying bacteremia or fungemia in patients with SIRS (a common risk factor for sepsis and acute lung injury), using PCR to detect previously undetectable organisms. Additionally, Dr. Doerschug will investigate the relationships between circulating microorganisms and the development of acute lung injury, focusing on patient physiology and outcomes. Once completed, these preliminary studies will more accurately describe the relationships between infection and inflammation in these disorders. Further studies can then focus on the modification of host responses to these infections. Throughout Dr. Doerschug's career development, he will interface with trainees in clinical research, pulmonary medicine, and microbiology. This intellectually rich environment will help foster the career development of Dr. Doerschug, providing ample opportunity for critical review throughout the period of this award. Both the mentor and the institution are highly committed to Dr. Doerschug's scientific development and academic success.