Ventilated Mouse Cages for NIH Funded Construction Projects

描述(由申请人提供)： 这个动物资源改良应用程序申请资金，为加州大学欧文分校(UCI)的动物设施购买通风小鼠笼子和动物转运站，以支持PHS资助的研究人员。具体地说，请拨的资金将用于在现有的吉莱斯皮·维瓦利姆的10个住房房间的36个单面通风笼架中设置笼子。位于吉莱斯皮神经科学研究设施的地下室，是最近最先进的实验室建设的中心，包括两个50,000个ASF实验室建筑(斯普拉格和休伊特大厅)，所要求的2,268个老鼠笼安装在一个1,515个ASF的联合等待区，也直接毗邻NCRR资助的两个建设项目：已建成的转基因啮齿动物设施(GMRF)和目前正在设计的程序/行为/住房套房(PBHS)。该项目的短期目标是解决UCI教职员工正在进行的PHS支持的生物医学研究中老鼠住房的直接和严重短缺问题。在过去的八年里，老鼠的使用率以平均每年30%以上的速度增长，这在很大程度上是由于关键教师的招聘和转基因技术的日益使用。在过去的三年里，校园在通风笼子上投资了200万美元，并在2002年成功地向NCRR提出了64.9万美元的动物资源改良申请。该校园计划在未来三年内向非NCRR基金投资至少300万美元，用于校园设施的笼子和相关设备。中央管理的大学实验动物资源(ULAR)的长期目标是以与密集的实验室建设和教师招聘相匹配的速度发展高质量的动物舍。这通过创建越来越多的能力来支持PHS资助的生物医学研究人员来支持该机构的使命。

DESCRIPTION (provided by applicant): This animal resource improvement application requests funds to purchase ventilated mouse cages and animal transfer stations for animal facilities at the University of California, Irvine (UCI), supporting PHS-funded researchers. Specifically, the requested funds would be invested in caging in 36 single-sided ventilated cage racks in 10 housing rooms in the existing Gillespie Vivarium. Located in the basement of Gillespie Neuroscience Research Facility and central to recent state-of-the-art laboratory construction, including two 50,000 ASF laboratory buildings (Sprague and Hewitt Hall), the requested 2,268 mouse cages, installed in a combined holding area of 1,515 ASF, also are directly adjacent to two NCRR-funded construction projects: the completed Genetically Modified Rodent Facility (GMRF) and the Procedural/Behavioral/Housing Suites (PBHS), currently in design. The short-term goal of this project is to address an immediate and serious shortfall in mouse housing for ongoing PHS-supported biomedical research by UCI faculty. Mouse use has increased at an average rate of 30+% per year over the last eight years, due in large part to key faculty recruitment combined with increasing use of transgenics. In the past three years the campus has invested $2 million in ventilated caging, supplemented by a successful $649,000 animal resource improvement application to NCRR in 2002. The campus plans to invest a minimum of $3 million in non-NCRR funds in caging and associated equipment for campus facilities in the next three years. The long-term goal of the centrally administered University Laboratory Animal Resources (ULAR) is to develop quality animal housing at a pace that matches intensive laboratory construction and faculty recruitment. This supports the agency's mission by creating a growing capacity to support PHS-funded biomedical researchers.