A Genetic Investigation of Regeneration in Drosophila

描述（由申请人提供）：一个迷人的生物学现象，其中细胞生长和分裂，尽管背景和历史，应该防止增殖是受损组织的再生。各种生物体和组织都有再生能力，有些组织如青蛙的四肢和果蝇的幼虫随着时间的推移会失去再生能力。因此，这些生物体含有可以克服细胞正常程序并诱导细胞分裂的基因，以及可以阻止这种细胞周期进程的基因。这里提出的工作旨在确定调节再生生长的基因。首先，将开发一种测定系统，通过该系统可以对果蝇的再生进行遗传学研究。其次，将进行基因筛选，以分离组织消融后影响再生生长的突变。第三，控制这一过程的基因和蛋白质将被鉴定和表征。调节再生生长的基因也可能调节癌症的进展。在再生和癌症进展过程中特异性调节细胞分裂的基因的鉴定可以提供独特的治疗靶点。

DESCRIPTION (provided by applicant): A fascinating biological phenomenon in which cells grow and divide despite a context and history that should prevent proliferation is the regeneration of damaged tissues. Various organisms and tissues are capable of regenerating, and some tissues such as frog limbs and fruit fly larvae lose their ability to regenerate over time. Therefore, these organisms contain genes that can overcome a cell's normal program and induce cell division, and genes that can prevent this cell cycle progression. The work proposed here is designed to identify genes that regulate regenerative growth. First, an assay system will be developed through which regeneration in Drosophila may be studied genetically. Second, genetic screens will be conducted to isolate mutations that affect regenerative growth after tissue ablation. Third, the genes and proteins that control this process will be identified and characterized. Genes that regulate regenerative growth may also regulate the progression of cancers. The identification of genes that specifically regulate cell division during regeneration and cancer progression may provide unique therapeutic targets.