Implantable DC Ablation Device for Tumor Therapy

描述（由申请人提供）：先进医疗电子（AME）提出开发一种用于治疗实体癌性肿瘤的植入式直流（DC）消融装置的原型。最近的数据支持这样的假设：对于那些以前没有或很少有有效治疗方案的患者，包括那些不可切除的肝脏或胰腺肿瘤患者，DC消融提供了一个可行的治疗选择。提出的植入式直流消融装置将以比其他消融治疗更低的速率提供能量。治疗过程可能持续几个小时到几天，如果需要，可能会重复几周。植入式系统克服了直流消融的主要缺点：治疗递送时间长。遥测植入物封装、电极设计和电池技术的最新进展使得植入式直流烧蚀装置在技术上是可行的。本课题的目的是设计、制造和测试一种适合用于大鼠模型的实验性植入装置，以评估直流消融的抗肿瘤效果。

DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) proposes to develop a prototype implantable direct-current (DC) ablation device for treating solid cancerous tumors. Recent data support the hypothesis that DC ablation offers a viable treatment option to patients who previously had few or no effective therapy alternatives, including those with unresectable liver or pancreatic tumors. The proposed implantable DC ablation device will deliver energy at a lower rate than other ablative therapies. Therapy sessions may last from several hours to a few days and may be repeated, if needed for several weeks. The implantable system overcomes the primary drawback of DC ablation: long therapy delivery time. Recent advances in telemetry implant packaging, electrode design, and battery technology make an implantable DC ablation device technically feasible at this time. The objective of this project is to design, build, and test an experimental implant device suitable for use in experiments to evaluate the anti-tumor efficacy of DC ablation in a rat model.