Graduate Training in Cancer Research

描述(申请人提供)：Dana-Farber癌症研究所(DFCI)于1973年被国家癌症研究所指定为综合性癌症中心。两年后，1975年，研究所首次获得机构国家研究服务奖(T32-CA09172)。自那时以来，已有314名个人得到了这笔赠款的资助(其中75%以上仍在学术岗位上)，这一资助机制已成为研究所培养临床研究人员能力的重要组成部分。这项建议的目的是请求继续支持未来五年，为希望从事学术肿瘤学职业的研究生医生提供研究培训。此应用程序的具体目的是为已完成内科或儿科肿瘤学培训的高度精选的临床医生提供临床、健康服务或实验室调查方面的经验。DFCI提供了广泛的研究环境，为交流思想和设计研究计划提供了一个不同寻常的肥沃环境。将继续通过定期安排的讲座、临床和研究会议以及“湿板凳”和“干板凳”实验室活动来提供培训。目前，发展部的研究设施包括七栋建筑，总面积为1,165,000平方英尺，用于研究所内的调查活动。包括内科和儿科肿瘤学、癌症生物学、癌症免疫学和艾滋病以及生物统计科学系在内的五个独立的系提供了广泛的研究机会。这项建议支持的受训人员可以从所有这些实验室中进行选择，作为他们希望进行研究的领域。该研究所的所有成员都在哈佛大学担任教职，并参加课堂陈述、实验室和临床研究培训。除了这笔机构赠款提供的培训支持外，DFCI调查人员还通过他们在邻近的哈佛附属医院的系级教员任命参加哈佛大学的博士后和博士后培训项目。2000年，该研究所的综合癌症中心地位扩大到包括与哈佛医学院、哈佛大学公共卫生学院和附属医院相关的所有生物医学设施(即Dana-Farber/哈佛癌症中心[DF/HCC])；DF/HCC核心赠款在2000年第一次审查时和2005年6月再次审查时都获得了杰出的评级。这项提案中描述的计划的目标是鼓励学术肿瘤学家的发展，他们将主要在该研究所进行研究活动，而不是在其他哈佛附属机构。预计在培训结束时，受该计划支持的个人将有能力独立或在最低限度的监督下设计、启动和完成个人研究项目，此后不久将能够确立自己作为独立研究调查人员的地位。

DESCRIPTION (provided by applicant): The Dana-Farber Cancer Institute (DFCI) was designated as a comprehensive cancer center by the National Cancer Institute in 1973. Two years later, in 1975, the Institute was initially awarded an institutional National Research Service Award (T32 -CA09172). Since that time, 314 individuals have been supported by this grant (more than 75% of whom remain in academic positions) and this funding mechanism has become an essential component in the ability of the Institute to develop clinical investigators. The purpose of this proposal is to request continued support for another five years to provide research training for postgraduate physicians who desire a career in academic oncology. The specific purpose of this application is to offer an experience in clinical, health services, or laboratory investigation to highly selected clinicians who have completed their training in medical or pediatric oncology. The availability of a wide spectrum of research environments within the DFCI offers an unusually fertile environment for the exchange of ideas and for collaboration in the design of research programs. Training will continue to be provided through regularly scheduled lectures, clinical and research conferences, and both "wet bench" and "dry bench" laboratory activities. The research facilities of the DFCI presently include seven buildings containing 1,165,000 gross square feet for investigative activities now contained within the Institute. Five separate departments including Medical and Pediatric Oncology, Cancer Biology, Cancer Immunology and AIDS, and Biostatistical Science offer a wide panoply of investigative opportunities. Trainees supported by this proposal are able to select from among all of these laboratories as the area in which they wish to conduct their research. All members of the Institute staff hold faculty appointments at Harvard University and participate in classroom presentations and laboratory and clinical research training. In addition to the training support provided by this institutional grant, DFCI investigators also participate in pre- and postdoctoral training programs at Harvard University through their departmental faculty appointments of at neighboring Harvard-affiliated hospitals. In 2000, the Institute's comprehensive cancer center status was expanded to embrace all of the biomedical facilities associated with Harvard Medical School, the Harvard University School of Public Health, and affiliated hospitals (i.e. Dana-Farber/Harvard Cancer Center [DF/HCC]); the DF/HCC core grant received an outstanding rating both at the time of its initial review in 2000 and when reviewed again in June, 2005. The goal of the program described in this proposal is to encourage the development of academic oncologists who will perform their investigative activities primarily at the Institute as opposed to other Harvard-affiliated facilities. It is expected that at the conclusion of their training, those individuals supported by this program will have the capability for designing, initiating, and completing individual research projects, independently or with minimal supervision, and soon thereafter will be able to establish themselves as independent research investigators.