From Bench to Bedside: Molecular Stories of Research-Based Health Care

描述(由申请人提供)： 这个项目的目标是开发以探究为基础的课程单元(ICU)，以研究型卫生保健的“分子故事”的形式呈现分子结构的基本概念。这些ICU将由MSOE生物分子建模中心(CBM)的工作人员、具有课程编写经验的资深教师、将为每个ICU开发评估工具的科学教育研究人员以及因沉浸式专业发展经验而熟悉ICU主题的高中科学教师组成的团队开发。 专业发展计划从建立的暑期课程-基因、方案和分子机器开始，更新教师关于分子结构和功能基本概念的内容知识。暑期课程之后是为期一周的建模研讨会，老师们选择一种有趣的人类疾病，并在创建受影响蛋白质的物理模型的同时探索疾病的分子基础。在接下来的一年里，教师将在他们的学校组织一个聪明的团队(学生为研究主题建模)，并直接与当地大学的基础或临床研究人员互动，创建蛋白质的物理模型，作为疾病的药物靶点。在这个多组成部分、深入探索疾病的分子基础及其治疗的暑假，教师们将作为ICU设计团队的成员参加。每个ICU将遵循标准的探究驱动的形式，为学生提供机会通过积极的、动手的建模活动来发现分子结构的基本概念。然后将这些知识以强调批判性思维技能的方式应用到临床情况中。 在这个项目中开发的ICU将在CBM工作人员和参与教师的演示和研讨会中广泛传播给其他教师，通过威斯康星州科学奥林匹克的蛋白质建模活动向学生广泛传播，在密尔沃基男孩女孩俱乐部的外展计划中向学生传播，并在我们当地探索世界博物馆主办的一系列公开讲座中向成人学习者传播。每个ICU的共同主题是NIH支持的基础和临床研究在开发治疗人类疾病的新分子方法方面所发挥的关键作用。

DESCRIPTION (provided by applicant): The goal of this project is to develop Inquiry-based Curriculum Units (ICUs) that present basic concepts of molecular structure in the form of "molecular stories" of research-based health care. These ICUs will be developed by a team of science educators composed of staff of the MSOE Center for BioMolecular Modeling (CBM), a veteran teacher with curriculum writing experience, a science education researcher who will develop assessment instruments to accompany each ICU, and high school science teachers who are familiar with the ICU topic as a result of an immersive professional development experience. The professional development program begins with an established summer course, Genes, Schemes and Molecular Machines, which updates the teachers' content knowledge of basic concepts of molecular structure and function. This summer course is followed by a week-long Modeling Workshop in which teachers select an interesting human disease, and explore the molecular basis of the disease while creating physical models of the affected proteins. During the ensuing academic year, teachers will organize a SMART Team (Students Modeling A Research Topic) in their schools and interact directly with a basic or clinical researcher at a local university to create a physical model of the protein that serves as a drug target for the disease. In the summer following this multi-component, in-depth exploration of the molecular basis of a disease and its treatment, the teachers will participate as members of the ICU Design Team. Each ICU will follow a standard inquiry-driven format that provides opportunities for students to discover basic concepts of molecular structure through active, hands-on modeling activities. This knowledge is then applied to the clinical situation in a way that emphasizes critical thinking skills. The ICUs that are developed in this project will be broadly disseminated to other teachers in presentations and workshops given by CBM staff and the participating teachers, to students through a Protein Modeling event of the Wisconsin Science Olympiad , in an outreach program to students of the Milwaukee Boys & Girls Club, and to adult learners in a series of public lectures hosted by our local Discovery World Museum. The common theme of each ICU is the critical role played by NIH-supported basic and clinical research in the development of new molecular approaches to the treatment of human diseases.