Formin' actin filaments associated with cancer

肌动蛋白丝是每个细胞内蛋白质纤维动态网络的一部分，在细胞形状、运动和分裂中发挥作用。癌细胞劫持特定类型的肌动蛋白丝扩散到全身。我们的目标是找出蛋白质机器是如何从肌动蛋白和不同的结合蛋白中组装这些纤维的，这些结合蛋白赋予了每个纤维特定的功能。这一发现将使我们能够改进抑制与癌症相关的纤维的药物。

Actin filaments are part of a dynamic network of protein fibres inside each cell and play a role in cell shape, movement and division. Cancer cells hijack specific types of actin filaments to spread throughout the body. Our aim is to find out how protein machines assemble these filaments from actin and different binding proteins that give each filament its specific function. This insight will allow us to improve drugs that inhibit filaments associated with cancer.