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Regulatory Circuits and Virulence in Candida albicans

Regulatory Circuits and Virulence in Candida albicans
白色念珠菌的调节回路和毒力
批准号：
7028471
负责人：
ALEXANDER D JOHNSON
金额：
$68.63万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-03-01 至 2011-02-28
来源：
https://reporter.nih.gov/project-details/7028471
关键词：
Candida albicansDNA binding proteinDNA footprintingfungal geneticsgene induction /repressiongene mutationgenetic techniqueslaboratory mousemicroarray technologymicroorganism growthtechnology /technique developmenttransposon /insertion elementvirulence

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中文摘要
翻译
描述（由申请方提供）：酵母菌白色念珠菌是哺乳动物消化道中的一种寄生生物。它也是最常见的人类真菌病原体，引起粘膜和全身感染，特别是在免疫功能低下的人群中。该提案涵盖了念珠菌六个不同方面的研究，其中五个涉及致病方面。(The第六章还没有研究过）。这些领域是（1）可逆的芽生孢子到丝状形态学的转变，（2）菌丝顶端细胞的特化，（3）白色-不透明的转换，（4）交配，（5）“毒力”基因的鉴定，（6）受调节的RNA剪接在毒力中的可能作用。
英文摘要
DESCRIPTION (provided by applicant): The yeast Candida albicans is found as a commensal organism in the digestive tract of mammals. It is also the most common human fungal pathogen, causing both mucosal and systemic infections, particularly in immunocompromised people. This proposal covers studies of six different aspects of Candida five of which have been implicated in aspects of pathogenesis. (The sixth has not yet been studied.) These areas are (1) the reversible blastospore to filament morophologica transitions, (2) specialization of hyphal tip cells, (3) white-opaque switching, (4) mating, (5) the identification of 'virulence' genes and, (6) the possible role of regulated RNA splicing in virulence.
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Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
Regulatory Circuits and Virulence in Candida albicans
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