CANCER GENETICS NETWORK

虽然癌症遗传学正在快速发展，但关于遗传易感性和预防的关键问题仍未得到解答。针对癌症遗传学网络的RFA，我们建议：(1)在CGN中招募大量以下人群：(a)遗传性乳腺癌、卵巢癌和结肠癌家族，(b)新诊断的高风险乳腺癌患者，(c)低至中度癌症风险人群；(2)利用我们现有的社区医院和初级保健诊所网络，增加华盛顿特区非洲裔美国人和拉丁美洲人的CGN入学率；(3)将我们经过验证的irb批准的知情同意、测试前教育和遗传咨询方案提交给CGN；(4)为中广核研究人员提供我们最先进的实验室技术，用于诊断基因分析；(5)利用我们现有的癌症DNA/组织收集、处理和储存基础设施，为中国核中心的基础癌症遗传学研究做出贡献；(6)修改现有的针对非裔美国人的癌症遗传学教材，开发西班牙语教材、知情同意书和咨询协议，供拉丁美洲人使用；(7)为广泛的医疗保健提供者，包括护士和医学生，提供遗传学教育和培训方案；(8)在癌症易感性基因检测的临床、社会心理和经济结果研究方面贡献我们的专业知识。

While advances in cancer genetics are occurring at rapid pace, critical questions about genetic susceptibility and prevention remain unanswered. In response to the RFA for the Cancer Genetics Network, we propose to: (1) Enroll substantial numbers of the following populations into the CGN: (a) hereditary breast, ovarian, and colon cancer families, (b) newly diagnosed high risk breast cancer patients, and (c) persons at low to moderate risk of cancer; (2) Utilize our existing networks of community-based hospitals and primary care clinics to increase CGN enrollment of African Americans and Latin Americans in the Washington, D.C. area; (3) Contribute our well-validated IRB-approved protocols for informed consent, pre-test education, and genetic counseling to the CGN; (4) Provide CGN investigators with access to our state-of-the-art laboratory technologies for diagnostic genetic analysis; (5) Utilize our existing infrastructure for cancer DNA/tissue collection, processing, and storage to contribute to basic cancer genetics research in the CGN; (6) Modify existing cancer genetics educational materials to target African Americans and develop Spanish language materials, consent forms and counseling protocols for use with Latin Americans; (7) Provide genetics education and training programs for a wide range of healthcare providers, including nurses and medical students; and (8) Contribute our expertise conducting research on the clinical, psychosocial, and economic outcomes of genetic testing for cancer susceptibility.