Multimodal imaging and analysis for monitoring physiological changes during brain injury

在英国，每年有10万例中风病例，16万人因创伤性头部损伤入院。据估计，超过200万人因中风或头部损伤而长期衰弱。目前，我们缺乏有效治疗和监测脑损伤的工具。开发新疗法的一个主要限制是我们对创伤性和非创伤性损伤期间和之后脑组织的功能和状况缺乏了解。该项目将开发和应用分子成像和microRNA分析来监测脑损伤期间和之后脑组织的生理和分子生物标志物。中风和创伤性脑损伤的啮齿动物模型将用于比较不同病理的方法和结果。磁共振成像（MRI）和microRNA数据集的比较和交叉验证将增强获得的生物学数据并增加临床转化的可能性。这个高度跨学科的项目将涉及化学合成，组织学，体内实验，以及MRI和microRNA数据集的分析。管理团队和实验设施涵盖多个互补部门，包括医学院、化学学院、心理学院、曼斯菲尔德爵士成像中心和精确成像信标学院，以及大华银行的炎症和衰老研究所。

Annually in the UK, there are 100,000 strokes and 160,000 people admitted to hospital with a traumatic head injury - it is estimated that over 2 million people live with the long-term, debilitating consequences of a stroke or head injury.Currently, we lack tools for effectively treating and monitoring brain injuries. One major limitation in developing new therapies is our lack of knowledge of the function and condition of brain tissue during and after traumatic and non-traumatic injury.This project will develop and apply molecular imaging and microRNA analyses to monitor the physiological and molecular biomarkers of brain tissue during and after brain injuries. Rodent models of both stroke and traumatic brain injury will be used to compare approaches and results across pathologies. Comparison and cross-validation of magnetic resonance imaging (MRI) and microRNA datasets will enhance the biological data obtained and increase likelihood of clinical translation.This highly interdisciplinary project will involve chemical synthesis, histology, in vivo experiments, and analysis of MRI and microRNA datasets. The supervisory team and experimental facilities spans multiple complimentary departments, including the Schools of Medicine, Chemistry, Psychology, Sir Peter Mansfield Imaging Centre, and Precision Imaging Beacon at UoN, and Institute of Inflammation and Ageing at UoB.