Single Shot OCT

描述（由申请人提供）：光谱域光学相干断层扫描（SDOCT）彻底改变了生物医学成像应用的低相干干涉测量方法。SDOCT同时检测来自焦体积中每个范围门的信号，从而实现超高的采集速度，提高信噪比，并改善相位稳定性。与10多年前的传统OCT一样，SDOCT首次在体内得到验证，在眼科领域最有希望用于疾病诊断。物理科学公司建议通过创建和开发单镜头光学相干层析仪（SSOCT）来扩展SDOCT的维度。ssot将通过成像光谱仪同时捕获完整的二维（2D）横截面。它将允许在几分之一秒内收集完整的三维（3D）深度分辨率地图。此外，SSOCT降低了前端横向扫描引擎的复杂性，并可能导致更多便携式仪器的发展。在眼科学中，眼动的有害影响将变得无关紧要，新的功能和泵-探针成像技术将最终取得成果。SSOCT建立在SDOCT和OCT的基础上，具有早期发现各种视网膜病变的潜力，从青光眼到黄斑变性。研究与公共卫生的相关性：拟议的研究将导致早期和改进视网膜疾病的诊断，如青光眼、糖尿病视网膜病变和年龄相关性黄斑变性。此外，所开发的仪器及其所依据的原理可用于对整个人体的其他疾病类型进行成像。

DESCRIPTION (provided by applicant): Spectral domain optical coherence tomography (SDOCT) has revolutionized the methodology of low coherence interferometry for biomedical imaging applications. SDOCT detects signals from every range gate in a focal volume simultaneously, allowing ultra-high acquisition speeds, increased signal-to-noise ratio, and improved phase stability. Like conventional OCT more than 10 years ago, SDOCT has been demonstrated in vivo first, and hold the most promise for disease diagnosis in the field of ophthalmology. Physical Sciences Inc. proposes to extend the dimensionality of SDOCT with the creation and development of a single-shot optical coherence tomographer (SSOCT). SSOCT will capture full two-dimensional (2D) cross-sections simultaneously with an imaging spectrograph. It will allow full three-dimensional (3D) depth-resolved maps to be collected in a fraction of a second. Moreover, SSOCT reduces the complexity of the front-end transverse scan engine and may lead to the development of more portable instruments. In ophthalmology, the pernicious effects of eye motion will be rendered inconsequential and new functional and pump-probe imaging techniques can finally reach fruition. SSOCT, built upon the foundation of SDOCT and OCT, has the potential for early detection of a wide range of retinal pathologies, from glaucoma to macular degeneration. Relevance of research to public health: The proposed research will lead to earlier and improved diagnosis of retinal diseases such as glaucoma, diabetic retinopathy and age-related macular degeneration. In addition, the developed instrument and the principles upon which it is based may be used to image other disease types throughout the human body.