Multimode Adaptive Optics Retinal Imager for Diagnosis of Age-Related Macular Deg

描述（由申请人提供）： (PSI)与匹兹堡大学医学中心（UPMC）眼科中心的临床医生和来自马萨诸塞州理工学院（MIT）的顾问合作，提出开发一种新颖的紧凑型多模自适应光学（AO）视网膜成像系统来研究年龄相关性黄斑变性（AMD）的特征。该系统将集成AO、基于扫频光源的傅立叶域光学相干断层扫描（FDOCT）和扫描激光检眼镜（SLO）。它还将包括许多临床增强功能，包括用于稳定成像的视网膜跟踪。该系统将依次采集视网膜细胞和结构的共配准面扫描激光检眼镜（SLO）和横截面OCT图像。在第一阶段，我们将设计和建造包括AO和扫频光源组件的光学核心。在第二阶段，我们将完成原型临床仪器，并在UPMC对患有AMD的人类受试者进行测试。我们将探讨玻璃疣的精细结构和边缘与光感受器的关系，评估布鲁赫膜的不连续性，并检查疾病开始和进展期间视网膜中其他敏感的相邻结构。所提出的系统有可能在疾病形成的最早阶段解决活体眼睛中的视网膜细节。这将为充分了解AMD的病因和机制提供信息，导致早期检测的方法，并帮助确定新的遗传和分子疗法的疗效。公共卫生相关性：通过使高分辨率的眼睛访问更广泛，拟议的仪器将开始带来自适应光学技术，以更多的临床医生和科学家。反过来，这些研究人员将利用这一工具来增加我们对视力及其被年龄相关性黄斑变性等疾病破坏的理解，并开发新的药物和疗法。

DESCRIPTION (provided by applicant): (PSI), in collaboration with clinicians at University of Pittsburgh Medical Center (UPMC) Eye Center and a consultant from Massachusetts Institute of Technology (MIT), propose to develop a novel compact multimode adaptive optics (AO) retinal imaging system to study the characteristics of age-related macular degeneration (AMD). The system will integrate AO, swept-source based Fourier domain optical coherence tomography (FDOCT), and scanning laser ophthalmoscopy (SLO). It will also include many clinical enhancements including retinal tracking for stabilized imaging. The system will sequentially acquire co-registered en-face scanning laser ophthalmoscopy (SLO) and cross- sectional OCT images of retinal cells and structures. In Phase I, we will design and construct the optical core including AO and swept source components. In Phase II, we will complete the prototype clinical instrument and test on human subjects with AMD at UPMC. We will explore the fine structure and margins of drusen in relation to photoreceptors, assess Bruch's membrane for discontinuity, and examine other sensitive adjacent structures in the retina during initiation and progression of the disease. The proposed system has the potential to resolve retinal details in the live eye at the very earliest stages of disease formation. This will provide information for full understand of the etiology and mechanisms of AMD, lead to methodologies for early detection, and help determine the efficacy of new genetic and molecular therapies. PUBLIC HEALTH RELEVANCE: By making high-resolution ocular access more widespread, the proposed instrument will begin to bring adaptive optics technology to a greater number of clinicians and scientists. These researchers will, in turn, use this tool to increase our understanding of vision and its disruption by diseases such as age-related macular degeneration and for the development of new drugs and therapies.