High Performance Multimodal Adaptive Optics Retinal Imaging

高性能多模态自适应光学视网膜成像

• 批准号: 8000497
• 负责人: DANIEL X HAMMER
• 金额: $ 67.41万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8000497
• 关键词: Academic Medical Centers; Age related macular degeneration; Age-Years; Algorithms; Area; Atrophic; Biochemical; Blindness; Blood Vessels; Blood capillaries; Bruch' s basal membrane structure; Cell Death; Cells; Characteristics; Choroid; Clinical; Clinical Trials; Collaborations; Coupled; Cues; Databases; Degenerative Disorder; Development; Device or Instrument Development; Diabetic Retinopathy; Diagnosis; Disease; Disease Progression; Disorder by Site; Drusen; Dyes; Equipment; Evaluation; Eye; Genetic; Glaucoma; Government; Human; Image; Imagery; Imaging Device; Inherited; Investigation; Lasers; Learning; Licensing; Light; Lighting; Lipofuscin; Manufacturer Name; Marketing; Measurement; Measures; Medical center; Microaneurysm; Modification; Motion; Nature; Nerve Fibers; Ophthalmologist; Ophthalmoscopes; Ophthalmoscopy; Optic Disk; Optical Coherence Tomography; Optics; Outcome; Patients; Penetration; Performance; Persons; Pharmaceutical Preparations; Pharmacotherapy; Phase; Photoreceptors; Population; Price; Production; Public Health; Reporting; Reproducibility; Research; Research Personnel; Resolution; Retinal; Retinal Cone; Retinal Degeneration; Retinal Diseases; Retinitis Pigmentosa; Sales; Scanning; Scientist; Screening procedure; Signal Transduction; Site; Small Business Innovation Research Grant; Source; Staging; Stimulus; Stroke; System; Technology; Testing; Time; Tissues; Universities; Validation; Vascular Diseases; Vision; Visit; Visual; adaptive optics; arm; base; capillary; clinically relevant; commercialization; cost; design; eye center; fovea centralis; ganglion cell; geographic atrophy; human subject; image registration; improved; insight; instrument; interest; macula; neovascularization; neuronal cell body; operation; optical imaging; physical science; product development; programs; prototype; public health relevance; research clinical testing; retinal nerve fiber layer; sample fixation; therapy development; tool

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) has successfully completed a Phase I program to develop a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa (RP). The development represents the first ever high performance AO system constructed that combines AO- corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. The SSOCT channel operates at a wavelength of 1 5m for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. The system is designed to operate on a broad clinical population with a dual deformable mirror (DM) configuration that allows simultaneous low- and high- order aberration correction. The system also includes a wide field line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation; an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of rotational eye motion; and a high-resolution LCD-based fixation target for presentation to the subject of stimuli and other visual cues. The system was tested in a limited number of human subjects without retinal disease for performance optimization and validation. The system was able to resolve and quantify cone photoreceptors across the macula to within ~0.5 deg (~100-150 5m) of the fovea, image and delineate ten retinal layers, and penetrate to resolve targets deep into the choroid. In addition to instrument hardware development, analysis algorithms were developed for efficient information extraction from clinical imaging sessions, with functionality including automated image registration, photoreceptor counting, strip and montage stitching, and segmentation. In collaboration with ophthalmologists and researchers at University of Pittsburgh Medical Center (UPMC) Eye Center, we propose to continue instrument development and full clinical testing in Phase II. The multimodal AO instrument will be refined and enhanced for clinical operation, including upgrades of the retinal tracker and synchronization hardware. In addition, we will outfit the instrument with a piezo-driven reference mirror for measurement of power Doppler signals from fine retinal capillaries. The system will be installed at UPMC for a two-stage clinical trial including initial validation in subjects without retinal disease and tests in subjects with glaucoma, DR, AMD, and RP. The study will demonstrate that the multimodal AO system provides structural and flow information not currently available from any other commercially- available imager. If successful, the Phase II program and subsequent Phase III commercial development will provide clinicians with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes. PUBLIC HEALTH RELEVANCE: By making high-resolution ocular access more widespread, the proposed high performance multimodal AO instrument will bring adaptive optics technology into use by a greater number of clinicians and scientists. These researchers will, in turn, use this tool to increase our understanding of vision and its disruption by disease and to measure tissue effects of new drugs and therapies.

描述(申请人提供)：物理科学公司(PSI)成功地完成了一项第一阶段计划，开发一种多模式自适应光学(AO)视网膜成像仪，用于诊断视网膜疾病，包括青光眼、糖尿病视网膜病变(DR)、老年性黄斑变性(AMD)和视网膜色素变性(RP)。这一开发是有史以来第一个高性能的声光系统，它将声光校正的扫描激光眼底镜(SLO)和扫描源傅立叶域光学相干断层扫描(SSOCT)成像模式结合在一个紧凑的临床原型平台上。SSOCT通道在1.5米波长下工作，以增加对脉络膜毛细血管和脉络膜的穿透和可视化，这两个部位是DR和湿性AMD的主要疾病活动部位。该系统采用双变形镜(DM)配置，可同时进行低阶和高阶像差校正，可在广泛的临床人群中运行。该系统还包括用于初始筛选、目标识别和全球定位的宽视场线扫描检眼镜(LSO)；集成的视网膜跟踪器(RT)，用于在存在旋转眼球运动的情况下稳定SLO、OCT和LSO成像场；以及基于LCD的高分辨率固定靶标，用于呈现刺激和其他视觉提示的对象。该系统在没有视网膜疾病的有限数量的人类受试者中进行了测试，以进行性能优化和验证。该系统能够分辨和量化黄斑中心凹至0.5°(~100-150 5m)范围内的视锥感光细胞，成像并勾画出10个视网膜层，并穿透以分辨目标至脉络膜深处。除了仪器硬件开发外，还开发了分析算法，以从临床成像会议中高效地提取信息，其功能包括自动图像配准、感光细胞计数、条带和蒙太奇拼接以及分割。我们与匹兹堡大学医学中心(UPMC)眼科中心的眼科医生和研究人员合作，计划在第二阶段继续仪器开发和全面临床测试。多模式声光仪器将进行改进和增强，以用于临床操作，包括升级视网膜跟踪器和同步硬件。此外，我们将为该仪器配备一个压电式参考镜，用于测量来自细小视网膜毛细血管的能量多普勒信号。该系统将安装在UPMC进行两个阶段的临床试验，包括在没有视网膜疾病的受试者中进行初步验证，以及在青光眼、DR、AMD和RP受试者中进行测试。这项研究将证明，多模式声光系统提供了目前任何其他商业成像仪都无法获得的结构和流动信息。如果成功，第二阶段计划和随后的第三阶段商业开发将为临床医生提供高分辨率、高性能的自适应光学成像，以帮助指导治疗、开发新药和改善患者结果。 与公共健康相关：通过使高分辨率眼科检查更广泛，拟议的高性能多模式声学检查仪器将使自适应光学技术被更多的临床医生和科学家使用。反过来，这些研究人员将使用这一工具来增加我们对视力及其疾病破坏的理解，并测量新药和疗法的组织效应。