Real-Time Three-Dimensional Motion Control Tracker

实时三维运动控制跟踪器

• 批准号: 6690168
• 负责人: DANIEL X HAMMER
• 金额: $ 10.22万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690168
• 关键词: bioimaging /biomedical imaging; fiber optics; heterodyning; imaging /visualization /scanning; interferometry; mathematics; ophthalmoscopy; optical tomography; phantom model; three dimensional imaging /topography; time resolved data

DESCRIPTION (provided by applicant): Image artifacts arising from object motion represent one of the largest challenges for the development of diagnostic clinical instrumentation. Real-time correction of motion-induced image artifacts is especially important in the development of systems with spatial resolution greater than the average range of incremental motion and with acquisition speed less than the average velocity of the tissue under investigation. Although post-processing algorithms for the restoration of images corrupted by blur have been utilized for a number of years, these algorithms usually rely on assumptions gathered from the acquired image, and thus are inherently inaccurate and slow. Physical Sciences Inc. (PSI) proposes to develop a real-time motion correction system, based upon interferometry, which includes high-speed, high-resolution, hardware-controlled tracking of motion in three-dimensions. The real-time motion control system incorporates depth tracking into PSI's mature transverse tracking capabilities. A prototype system will be designed, built, and tested on tissue phantoms in the Phase I program. Depth and transverse tracking bandwidth will be characterized and compared to theoretical calculations for several experimental arrangements. After optimization, the Phase II instrument will be tested in a clinical ophthalmic program and the improvement in measurement of retinal features (e.g., nerve fiber layer thickness) will be quantified.

描述（由申请人提供）： 由物体运动引起的图像伪影代表了诊断临床仪器开发的最大挑战之一。运动引起的图像伪影的实时校正在空间分辨率大于增量运动的平均范围并且采集速度小于所研究的组织的平均速度的系统的开发中尤其重要。尽管用于恢复被模糊破坏的图像的后处理算法已经使用了许多年，但是这些算法通常依赖于从所获取的图像收集的假设，并且因此固有地不准确和缓慢。物理科学公司(PSI)提出开发基于干涉测量的实时运动校正系统，其包括高速、高分辨率、硬件控制的三维运动跟踪。实时运动控制系统将深度跟踪功能整合到PSI成熟的横向跟踪功能中。在I期项目中，将在组织体模上设计、构建和测试原型系统。深度和横向跟踪带宽的特点，并比较几个实验安排的理论计算。优化后，第二阶段仪器将在临床眼科项目中进行测试，并改进视网膜特征的测量（例如，神经纤维层厚度）将被量化。