Real-Time Three-Dimensional Motion Control Tracker

实时三维运动控制跟踪器

• 批准号: 7125601
• 负责人: DANIEL X HAMMER
• 金额: $ 37.18万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-11-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125601
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; human subject; image enhancement; nursing research; ophthalmoscopy; optical tomography; retina; retina circulation; time resolved data

DESCRIPTION (provided by applicant): Physical Sciences Inc. has successfully completed a Phase I program that demonstrated the feasibility of three-dimensional tracking for motion stabilization. The developed system extends the capabilities of our patented, high-speed, non-imaging tracker specifically for optical coherence tomography (OCT) based diagnostic technology. For ophthalmic applications, the three-dimensional tracker will obviate the need for complicated post-processing image registration algorithms currently used in commercial clinical OCT systems. Moreover, the tracking system will improve state-of-the-art spectral domain OCT (SDOCT) and optical Doppler tomography (ODT and SDODT) systems for the measurement of retinal blood flow in the smallest capillaries with improved phase stability and a wider dynamic range. The system will enable unprecedented resolution of retinal structures, creation of speckle and noise-reduced composite images by averaging hundreds of images, the generation of high-resolution three-dimensional maps, and the ability to return to the exact same tissue location days, months, or years later. We propose herein to continue the development of the three-dimensional tracker in a Phase II program. The optical setup will be moved from the bench-top to a compact optical head mounted to a standard chin rest for retinal imaging. The instrumentation will likewise be moved from the laboratory to a small portable clinical cart. Other extensive optical, electronic, and mechanical modifications will make the system easy-to-use and easily modified for clinical technicians and researchers alike. The system will be tested for two applications. First and foremost, the system will be tested in human volunteers and the primary application will be ophthalmic diagnosis of retinal diseases, included defects in perfusion, where current techniques are limited by eye motion. Second, the system will be tested during in vivo imaging of the innominate artery of a genetically altered mouse for the specific research application of the identification and characterization of vulnerable plaque in coronary artery disease. Since the innominate artery lies directly over the heart, this investigation has been especially confounded by motion artifact. The progress made in Phase II will significantly enhance the tools ophthalmologist and researchers have at their disposal for in vivo diagnosis and treatment of a wide variety of diseases.

描述（由申请人提供）： 物理科学公司已经成功完成了第一阶段的计划，证明了三维跟踪运动稳定的可行性。开发的系统扩展了我们的专利，高速，非成像跟踪器的能力，专门用于光学相干断层扫描（OCT）的诊断技术。对于眼科应用，三维跟踪器将满足目前在商业临床OCT系统中使用的复杂后处理图像配准算法的需要。此外，该跟踪系统将改进用于测量最小毛细血管中的视网膜血流的最先进的谱域OCT（SDOCT）和光学多普勒断层扫描（ODT和SDOT）系统，具有改进的相位稳定性和更宽的动态范围。该系统将实现视网膜结构的前所未有的分辨率，通过平均数百张图像来创建斑点和降噪的复合图像，生成高分辨率的三维地图，并能够在几天，几个月或几年后返回到完全相同的组织位置。 我们建议在第二阶段计划中继续开发三维跟踪器。光学装置将从工作台移动到安装到标准下巴托的紧凑型光学头，用于视网膜成像。仪器同样将从实验室移动到小型便携式临床推车上。其他广泛的光学，电子和机械修改将使该系统易于使用，并易于为临床技术人员和研究人员修改。该系统将在两个应用程序中进行测试。首先，该系统将在人类志愿者中进行测试，主要应用将是视网膜疾病的眼科诊断，包括灌注缺陷，目前的技术受到眼球运动的限制。其次，该系统将在体内成像的无名动脉的基因改变的小鼠的冠状动脉疾病的易损斑块的识别和表征的具体研究应用进行测试。由于无名动脉直接位于心脏上方，因此这项研究尤其受到运动伪影的干扰。在第二阶段取得的进展将显着提高眼科医生和研究人员在体内诊断和治疗各种疾病的工具。