Stabilized Adaptive Optics Imaging Laser Microsurgery

眼科成像的最新进展已经彻底改变了临床医生可视化和理解各种眼睛疾病的能力。虽然这些先进的诊断仪器间接指示一个疗程，但它们通常不直接与特定的治疗相结合。我们建议设计、开发和构建一种创新的诊断仪器，其核心要素将成为提供一种新的治疗方式的组成部分。该诊断仪器将以扫描激光眼科检查（SLO）为核心，具有独特和必要的自适应光学增强和视网膜跟踪功能，用于提高成像性能和临床实用性。这仪器将被用来精确地测量

Recent advances in ophthalmic imaging have revolutionized the ability of clinicians to visualize and understand a wide variety of diseases of the eye. Although these advanced diagnostic instruments indirectly indicate a course of treatment, they are generally not directly coupled to a particular therapy. We propose to design, develop, and construct an innovative diagnostic instrument, the core elements of which will be integral to the delivery of a new treatment modality. The diagnostic instrument will use scanning laser ophthalmoscopy (SLO) at its core, with unique and necessary enhancements of adaptive optics and retinal tracking used to increase imaging performance and clinical utility. The instrument will be used to precisely deliver laser pulses for several different potential therapeutic applications. By use of ultrashort laser pulses of femtosecond or picosecond duration, microsurgical damage can be created at spatially-confined locations, without collateral damage to critical adjacent layers, and with lower energies than other laser surgery. The system will be constructed at Physical Sciences Inc. (PSI) and the imaging performance will be evaluated there on artificial targets and on a limited number of human subjects. The system will then be transported to the laser laboratory (AFRIJHEDO) at Brooks AFB for initial testing in an appropriate animal model. The PSI investigators will be assisted by experts in the field of adaptive optics for retinal imaging, clinical ophthalmology, and ultrashort pulse laser generation and delivery. The unique use of an advanced, high-resolution imaging system for both imaging and delivery of laser pulses for specific therapies constitutes the direct, complete, and efficient integration of detection and treatment modalities.