Stabilized Adaptive Optics Imaging Laser Microsurgery

眼科成像的最新进展已经彻底改变了临床医生可视化和理解各种眼睛疾病的能力。虽然这些先进的诊断仪器间接地指示治疗过程，但它们通常不直接与特定治疗相关联。我们建议设计，开发和构建一种创新的诊断工具，其核心要素将是一种新的治疗方式的提供不可或缺的。该诊断仪器将以扫描激光检眼镜（SLO）为核心，并对自适应光学和视网膜跟踪进行了独特和必要的增强，以提高成像性能和临床实用性。该仪器将用于精确地 为几种不同的潜在治疗应用提供激光脉冲。通过使用飞秒或皮秒持续时间的超短激光脉冲，可以在空间受限的位置处产生显微手术损伤，而不会对关键相邻层造成附带损伤，并且能量低于其他激光手术。 该系统将在物理科学公司建造。(PSI)并且将在那里对人造目标和有限数量的人类受试者评估成像性能。然后将系统运送至布鲁克斯空军基地的激光实验室（AFRIJHEDO），在适当的动物模型中进行初始测试。PSI研究人员将由视网膜成像、临床眼科学和超短脉冲激光产生和传输领域的自适应光学专家协助。先进的高分辨率成像系统在成像和激光脉冲输送方面的独特用途构成了检测和治疗模式的直接、完整和有效集成。

Recent advances in ophthalmic imaging have revolutionized the ability of clinicians to visualize and understand a wide variety of diseases of the eye. Although these advanced diagnostic instruments indirectly indicate a course of treatment, they are generally not directly coupled to a particular therapy. We propose to design, develop, and construct an innovative diagnostic instrument, the core elements of which will be integral to the delivery of a new treatment modality. The diagnostic instrument will use scanning laser ophthalmoscopy (SLO) at its core, with unique and necessary enhancements of adaptive optics and retinal tracking used to increase imaging performance and clinical utility. The instrument will be used to precisely deliver laser pulses for several different potential therapeutic applications. By use of ultrashort laser pulses of femtosecond or picosecond duration, microsurgical damage can be created at spatially-confined locations, without collateral damage to critical adjacent layers, and with lower energies than other laser surgery. The system will be constructed at Physical Sciences Inc. (PSI) and the imaging performance will be evaluated there on artificial targets and on a limited number of human subjects. The system will then be transported to the laser laboratory (AFRIJHEDO) at Brooks AFB for initial testing in an appropriate animal model. The PSI investigators will be assisted by experts in the field of adaptive optics for retinal imaging, clinical ophthalmology, and ultrashort pulse laser generation and delivery. The unique use of an advanced, high-resolution imaging system for both imaging and delivery of laser pulses for specific therapies constitutes the direct, complete, and efficient integration of detection and treatment modalities.