Compact Line-scanning Adaptive Optics Retinal Imager

紧凑型线扫描自适应光学视网膜成像仪

• 批准号: 7326336
• 负责人: DANIEL X HAMMER
• 金额: $ 20.12万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7326336
• 关键词: Arts; Bread; Characteristics; Clinic; Clinical; Clinical Research; Complex; Computer software; Computers; Condition; Consultations; Custom; Development; Disease; Disruption; Early Diagnosis; Engineering; Environment; Evaluation; Exclusion; Facility Construction Funding Category; Floods; Government; Housing; Image; Imaging technology; Interferometry; Laboratories; Laser Surgery; Lasers; Lead; Lighting; Measurement; Measures; Methods; Miniaturization; Modeling; Molecular; Molecular Genetics; Numbers; Ophthalmologist; Ophthalmology; Ophthalmoscopes; Ophthalmoscopy; Optical Coherence Tomography; Optics; Optometrist; Patients; Performance; Persons; Pharmacotherapy; Phase; Pilot Projects; Population; Postdoctoral Fellow; Psychophysics; Psychophysiology; Purpose; Range; Research; Research Personnel; Resolution; Retinal; Retinal Defect; Retinal Diseases; Running; Scanning; Scientist; Series; Signal Transduction; Source; Staging; Standards of Weights and Measures; Stimulus; Stroke; System; Technology; Testing; Training; Treatment Efficacy; Universities; Vision; White Blood Cell Count procedure; adaptive optics; commercialization; concept; cost; design; eye center; fluorescence imaging; ganglion cell; gene therapy; human subject; improved; instrument; instrumentation; laptop; model design; novel; performance tests; physical science; portability; programs; prototype; research clinical testing; research study; size; success; systems research; technological innovation; tool

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI), in consultation with an ophthalmologist from Duke Eye Center, proposes the development of a compact adaptive optics line-scanning laser ophthalmoscope (AO-LSLO). The instrument will greatly reduce the size, cost, and complexity of adaptive optics retinal cameras and lead to more wide-spread use of high-resolution imaging technology by ophthalmologist, optometrist, and vision researchers. In the proposed Phase I program, we will design and model the optical layout, construct a bench-top version of the instrument, and complete a series of experiments to characterize and optimize performance and determine concept feasibility. In a potential Phase II program, we will package the setup into a small housing designed to sit on a slit lamp stage. We will also perform clinical testing on human subjects with retinal diseases at Duke Eye Center in the second half of a Phase II program. The instrument will be amenable to clinical studies for the early detection and progression of retinal disease, direct measurement of the structural and functional characteristics of a wide range of retinal defects, microperimetry and psychophysical vision studies, and for determination of the efficacy of novel genetic and molecular therapies. By making high-resolution ocular access more widespread, the proposed instrument will begin to move adaptive optics technology into a greater number of clinicians and scientists. These researchers will, in turn, use this tool to increase our understanding of vision and its disruption by disease and for the development of new drugs and therapies.

描述（由申请人提供）：Physical Sciences Inc. (PSI)在与杜克眼科中心的眼科医生协商后，提出了一种紧凑型自适应光学线扫描激光检眼镜（AO-LSLO）的发展。该仪器将大大降低自适应光学视网膜相机的尺寸、成本和复杂性，并促使眼科医生、验光师和视觉研究人员更广泛地使用高分辨率成像技术。在拟议的第一阶段计划中，我们将设计和模拟光学布局，构建仪器的台式版本，并完成一系列实验，以表征和优化性能，并确定概念的可行性。在一个潜在的第二阶段计划中，我们将把设置打包到一个小的外壳中，该外壳设计成坐在裂隙灯台上。我们还将在杜克眼科中心对患有视网膜疾病的人类受试者进行第二阶段计划的下半部分的临床测试。该仪器将适用于临床研究，用于早期检测和视网膜疾病的进展，直接测量各种视网膜缺陷的结构和功能特征，微视野和心理物理视觉研究，以及确定新的遗传和分子疗法的疗效。通过使高分辨率的眼睛访问更广泛，拟议的仪器将开始移动自适应光学技术到更多的临床医生和科学家。反过来，这些研究人员将利用这一工具来增加我们对视力及其被疾病破坏的理解，并开发新的药物和疗法。