THE DINE STUDY - DIET INTERVENTION TO NEGATE DIABETES STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。理想情况下，饮食处方将改善心血管疾病的风险概况，即使实现了适度的体重减轻。实现这一理想对非裔美国人来说可能很重要，原因有两个：(1)饮食处方应该改善整体心血管健康，而不仅仅是一个危险因素；(2)改善心血管风险的最佳效果可能必须以较少的减肥量实现。该项目的目的是表征DASH饮食模式在减肥和不减肥的情况下对肥胖非裔美国人的胰岛素敏感性和选定的心血管危险因素的生理影响。研究参与者(n=93)将被随机分成三个8周喂养方案中的一个，其中包括等卡路里DASH饮食、低卡路里DASH饮食或低卡路里控制饮食(典型的美国摄入量)。这项研究设计将允许检验以下假设：(1)与低卡路里控制饮食的非裔美国人相比，等卡路里DASH饮食的非洲裔美国人在胰岛素敏感性方面将有更大的改善；(2)与非裔美国人相比，减肥DASH饮食的非洲裔美国人在胰岛素敏感性方面的改善将更大；以及(3)与等卡路里DASH饮食和低卡路里控制饮食对胰岛素敏感性的综合影响相比，减肥DASH饮食对胰岛素敏感性的影响将是次要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ideally, a dietary prescription would produce improvements in CVD risk profiles even with modest amounts of weight loss achieved. Achieving this ideal might be important for African American populations for 2 reasons: (1) the dietary prescription should improve overall cardiovascular health and not just one risk factor,(2) the optimal impact for improvement of cardiovascular risk may have to be achieved with lesser amounts of weight loss. The aim of this project is to characterize the physiologic effects of the DASH dietary pattern, with and without weight loss, on insulin sensitivity and selected CVD risk factors in obese African Americans. Study participants (n = 93) will be randomized to one of three, 8- week feeding protocols that include a isocaloric DASH diet, a hypocaloric DASH diet, or a hypocaloric control diet (typical American intake). This study design will allow the testing of the following hypotheses: (1) African Americans on an isocaloric DASH diet will have greater improvement in insulin sensitivity compared to African Americans on a reduced calorie, control diet; (2) African Americans on a weight reducing DASH diet will have greater improvement in insulin sensitivity compared to African Americans on a reduced calorie, control diet; and (3) the effects on insulin sensitivity of a weight reducing DASH diet will be sub-additive compared to the combined effects on insulin sensitivity of an isocaloric DASH diet and a reduced calorie control diet.