EATRIGHT FOLLOW UP STUDY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。背景资料：这项研究的主要目的是确定EatRight在最后一次参与日期为1-4年前的人中的长期有效性;次要目的是了解水果和蔬菜摄入量对体重维持的影响及其对疾病风险因素的影响。 研究问题：我们假设，在12周的EatRight干预期间，体重、腰围和BMI的变化将保持在95%的置信区间（CI）内。40%的人在干预后1至4年随访。次要假设指出，与一组匹配的对照组相比，那些保持50%体重减轻的人将有更高的水果和蔬菜摄入量，并更好地控制标准心血管和代谢疾病风险因素。 结局指标：对照组参与者将接受与前EatRight参与者相同的测量，包括体重，血压，血脂，葡萄糖，胰岛素，双能X射线吸收测定法的身体成分，以及4天食物记录的饮食摄入分析。两个队列将纵向随访2年，每年进行1次访视，以评估结局变量随时间的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: The primary aim of this study is to determine the long-term effectiveness of EatRight in those whose last date of participation was 1-4 years ago; secondary aims are to understand the impact of fruit and vegetable intake on weight maintenance and its impact on disease risk factors. Study question: We hypothesize that changes in weight, waist circumference and BMI during the 12-week EatRight intervention will be maintained within a 95% confidence interval (CI) of ? 40% of individuals at follow-up 1 to 4 years post-intervention. Secondary hypotheses state that, compared to a group of matched controls, those with maintenance of 50% of weight loss will have higher fruit and vegetable intake and better control of standard cardiovascular and metabolic disease risk factors. Outcome measures: Control participants will receive the same measures as former EatRight participants, including weight, blood pressure, lipids, glucose, insulin, body composition with dual energy X-ray absorptiometry, and analysis of dietary intake from 4-day food records. Both cohorts will be followed longitudinally for 2 years with 1 annual visit to assess changes over time in the outcome variables.