EFFECTS OF MEDIUM CHAIN TRIGLYCERIDE OIL IN A WEIGHT LOSS DIET

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。肥胖是一个压倒性的问题，减肥的人往往会在相对较短的时间内重新增加体重。拟议研究项目的主要目的是确定在减肥计划中加入MCT油是否会导致不同程度的体重减轻以及总体和局部脂肪质量下降，而不同于加入特轻橄榄油。第二个目的是测试MCT和添加橄榄油的减肥饮食在饱腹感和食欲水平以及代谢风险因素变化方面是否存在差异。50名超重的成年男性和女性，年龄在19-50岁之间，体重指数(BM)为27-33公斤/平方米，将被建议在16周内每天摄入1200千卡的女性和1500千卡的男性，以使体重减轻约0.5-1.0千克/周。每个人都将每周接受一次集体饮食咨询。减肥计划将是UAB已经实施的EatRight计划的修改版本。在这个减肥计划中，受试者将被随机分配到他们的能量处方中的10%作为MCT油或橄榄油，作为长链甘油三酯(LCT)的来源。提供这种水平石油的食品将由GCRC供应。身体成分将通过双能X射线吸收测量仪(DXA)和单层计算机断层扫描(CT)进行测量。这些测量将提供对身体脂肪质量以及腹部皮下和内脏脂肪组织的准确测量。体重、腰围和臀围将每两周测量一次。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is an overwhelming problem and individuals who lose weight tend to re-gain the weight within a relatively short period of time. The primary aim of the proposed research project is to determine whether the incorporation of MCT oil in a weight-loss program results in a different degree of weight loss and total and regional fat mass loss than the incorporation of extra light olive oil. The secondary aims are to test whether there are differences in perceived satiety and appetite levels and in changes in metabolic risk factors between the MCT and the olive oil-supplemented weight loss diets. Fifty overweight adult men and women between the ages of 19-50, body mass index (BM) 27-33 kg/m2, will be counseled to consume 1200 kcal/d for women and 1500 kcal/d for men for 16 wks to induce a weight loss of approximately 0.5-1.0 kg/wk. Each person will receive group dietary counseling on a weekly basis. The weight loss program will be a modified version of the EatRight program already in place at UAB. Within this weight loss plan, subjects will be randomly assigned to consume 10% of their energy prescription as either MCT oil or olive oil, as a source of long chain triglycerides (LCT). Food products providing this level of oil will be supplied by the GCRC. Body composition will be measured by dual energy X-ray absorptiometry (DXA) and single-slice computed tomography (CT). These measurements will provide accurate measures of body fat mass as well as abdominal subcutaneous and visceral adipose tissue. Body weight, waist circumference, and hip circumference will be measured bi-weekly.