Community Exposure to Perfluorooctanate

描述（由申请人提供） 该项目是宾夕法尼亚大学的环境研究人员、西弗吉尼亚州帕克斯堡健康南方医院的当地医疗保健提供者和迪凯特社区协会之间的合作伙伴关系，旨在解决小霍克水协会区（LHWAD）居民接触C8的问题。 Little Hocking是阿巴拉契亚地区西弗吉尼亚州帕克斯堡附近的一个村庄，直接位于俄亥俄州河对岸，位于一座向空气、地面和水中大量排放C8的工厂的顺风处。 已知LHWAD的居民通过空气、居民饮用水、家庭井水和社区水接触C8;一些居民有职业接触（可能有家庭污染）。 还有其他潜在的暴露源。 已知C8在环境和人体中具有很强的持久性（血清半衰期约为4年）。 C8可能对肝脏有毒，导致睾丸癌和乳腺增生，并可能对实验动物的生殖产生影响。 人体数据有限，但已报告了职业接触的不利影响。 围绕小霍金和周边地区C8污染的事件导致了大量社区的怀疑和缺乏信任。 通过该项目，合作伙伴将在居民分层抽样中测量C8，并确定各种潜在接触源的相对重要性。 为了帮助评估居民的C8风险水平，将与其他人群和职业群体进行比较，并确定毒性效应的早期生物标志物是否与较高的C8水平相关。 这些信息将与社区共享，并制定一项实施计划以减少接触。 将采用社区参与模式，让利益攸关方参与所有阶段。 将强调双向沟通，以及对社区居民和当地卫生从业人员的教育。 将评估沟通和教育的有效性以及居民的参与程度。 评估的结果指标包括血液C8水平的降低，以及通过独立的参与性研究是否恢复了社区信任。

DESCRIPTION (provided by applicant) This project is a partnership between environmental researchers at the University of Pennsylvania, local health care providers at Health South Hospital, Parkersburg WV, and the -Decatur Community Association, to address exposure of residents in the Little Hocking Water Association district (LHWAD) to C8. Little Hocking is a village in the Appalachian region near Parkersburg WV, located directly across the Ohio River and downwind of a plant with significant discharges of C8 to air, ground, and water. Residents of LHWAD have known exposures to C8 through air, residential drinking water domestic well water, and community water; some residents have occupational exposure (with possible domestic household contamination). There are other potential exposure sources. C8 is known to be very persistent in both the environment and in humans (serum half-life approximately 4 years). C8 can be toxic to the liver, causes testicular cancer and mammary hyperplasia and may have reproductive effects in experimental animals. Human data is limited but adverse effects have been reported from occupational exposure. Events surrounding C8 contamination in Little Hocking and surrounding areas have led to substantial community skepticism and lack of trust. Through this project the partners will measure C8 in a stratified sample of residents and identify the relative importance of the various potential exposure sources. To help assess C8 risk levels in residents will be compared with those in other population and occupational groups and by determining if early biomarkers of toxic effect are associated with higher C8 levels. This information will be shared with the community, and an implementation plan developed to reduce exposures. A community participation model will be used to involve stakeholders at all stages. Two-way communication, and education of community residents and local health practitioners will be emphasized. The effectiveness of communication and education and the level of participation of residents will be evaluated. Outcome measures to be evaluated include the reduction of levels of blood C8, and whether community trust is restored through an independent participatory study.