Simultaneous fMRI and Electrophysiology in Visual System

描述（由申请人提供）：本申请的目的是申请资金进行试点研究，以开发最先进的24位系统，用于在功能性MRI（fMRI）期间进行电生理记录（视觉诱发电位- VEP、局部场电位- LFP、多单位活动MU、单单位活动SU）。 我们目前已经开发了一个完整的32通道和24位系统的电生理记录，已在3 T系统进行了广泛测试。 此外，我们已经在3 T条件下进行了颅外EEG-fMRI联合实验，并且在技术上能够进行颅内LFP-fMRI实验。 最后，我们目前能够：（1）在3“1”处进行最先进的清醒猴fMRI实验。 我们建议升级现有的系统，以达到每通道30 kS/s的采样，（2）开发软件和MRI兼容的颅内电极。 我们将关联高分辨率清醒猴fMRI信号与电生理信号的同时记录与一组简单但有趣的视觉实验，以评估现有的和拟议的系统的质量。 鉴于全球缺乏用于电生理记录的市售MR兼容系统，MRI期间用于一般电生理的最终系统将成为视觉研究的高影响力工具。

DESCRIPTION (provided by applicant): The purpose of this application is to request funding to conduct pilot studies to develop a state-of-the-art 24-bit system for conducting electrophysiological recordings (visual evoked potentials - VEP, Local Field Potentials - LFP, Multi-Unit activity MU, Single-Unit activity SU) during functional MRI (fMRI). We currently have developed a complete 32-channel and 24-bit system for electrophysiological recording that has been extensively tested both at 3 T systems. Furthermore, we have already performed combined extracranial EEG-fMRI experiments at 3T and are technically able to perform intracranial LFP-fMRI experiments. Finally, we are currently able: (1) to perform state-of-the-art awake monkey fMRI experiments at 3"1". We propose to upgrade the existing system to attain 30kS/s sampling per channel, and (2) develop software and MRI compatible intracranial electrodes. We will correlate the high-resolution awake monkey fMRI signals with the simultaneous recording of electrophysiological signals with a set of simple but interesting visual experiments to evaluate the quality of both the existing and the proposed systems. The final system for general electrophysiology during MRI will become a high impact tool for vision research, given the worldwide lack of commercially available MR-compatible systems for electrophysiological recording.