Clinical System for Arterial Characterization

描述(申请人提供)：已发表的研究表明，可见波长反射率和荧光光谱学都是临床上识别易损斑块(VP)的很有前途的技术--一种容易破裂并产生动脉血栓的疾病。在正常的血管内窥镜检查中，反射率已经可见，黄色脂肪可通过白色纤维帽扩散，这取决于纤维帽的厚度，并形成VP的定性指标。通过定量光谱学识别VP的临床有用仪器的进展需要动脉、光纤侧视探头(SLP)。这是第二阶段计划的主要目标，通过建立第一阶段组织探针光谱模型，开发探针构建技术，并获得探针组织测量来实现这一点。在第二阶段计划中，将生产三种SLP设计，并在外周动脉进行临床测试。这些数据将被简化，以提供光谱分辨的漫反射和本征荧光。将与并行蒙特卡罗模拟的结果、病理学的结果以及其他人的测量结果进行比较，以确定组织的特征并识别具有明显脂质核心特征的薄纤维帽的病变。我们预计，将比色信息和本征荧光结合在一起会产生比单独使用其中任何一种更好的结果。

DESCRIPTION (provided by applicant): Published studies indicate that visible wavelength reflectance and fluorescence spectroscopy are each promising techniques for clinically recognizing vulnerable plaque (VP) - a condition prone to rupture and produce arterial thrombosis. Reflectance is already visually accessible in normal angioscopy, and yellow lipid may be seen diffusely through an otherwise white fibrous cap, depending on its thickness, and form a qualitative indication for VP. Progress toward a clinically useful instrument for recognizing VP by quantified spectroscopy requires an arterial, optical-fiber based side-looking probe (SLP). It is a primary goal of the Phase-2 program to accomplish this by building on the Phase-1 tissue-probe-spectroscopy modeling, probe construction techniques developed, and probe - tissue measurements obtained. In the Phase-2 program three SLP designs will be produced and clinically tested in peripheral arteries. The data will be reduced to provide spectrally resolved diffuse reflectance and intrinsic fluorescence. Comparison will be made to results from concurrent Monte Carlo modeling, results from pathology, and results from the measurements of others with respect to characterizing the tissue and recognizing lesions with thin fibrous caps with a significant lipid core - hallmarks of VP. We expect that bringing together the colorimetry information with intrinsic fluorescence will produce results better than either alone.