Fundamental advancement of knowledge of Plasmodium vivax biology, drug susceptibility and transmission

间日疟原虫是分布最广的疟疾寄生虫，每年造成8 000多万例病例。然而，目前对付这种寄生虫的手段严重不足。由于无法获得连续培养、高通量药物检测以及对传播的了解不足，存在着巨大的知识差距。这抑制了间日疟原虫新疗法的开发。该项目将从根本上推进这种重要但被忽视的病原体的生物学和流行病学知识。

Plasmodium vivax is the most widespread malaria parasite causing over 80 million cases per year. Yet, current means to counter this parasite are grossly inadequate. Vast knowledge gaps exist due to unavailability of continuous cultures, high throughput drug assays and the poor understanding of transmission. This inhibits the development of new treatments for P. vivax. This project will fundamentally advance knowledge of the biology and epidemiology of this important, but neglected pathogen.