Crystallographic Studies of Chemokines, Chemokine Recept

本节主要研究通过趋化性的细胞间信号传导的结构基础，以及趋化因子和防御素在病毒感染过程中的作用。我们也对防御素和趋化因子的结构与其抗菌和趋化特性的关系感兴趣。我们也在研究人类l -天冬酰胺酶和植物型天冬酰胺酶的酶促机制和特异性，尿激酶纤溶酶原激活物复合物及其受体的结构以及TREM-Like Transcript protein 1 （TLT-1）。虽然我们主要使用x射线晶体学在我们的研究中，我们的研究技术扩展到生物化学和分子生物学。

Our section is investigating the structural basis of intercellular signaling via chemotaxis and the role of chemokines and defensins in the process of viral infection. We are also interested in correlating the structures of defensins and chemokines with their antimicrobial and chemotactic properties. We are also studying the enzymatic mechanism and specificity of human L-asparaginase and plant-type asparaginases, structures of urokinase plasminogen activator complex with its receptor as wel as TREM-Like Transcript protein 1 (TLT-1). Although we primarily use X-ray crystallography in our studies, our research techniques extend into biochemistry and molecular biology.