Clinical System for Arterial Characterization

描述（由申请人提供）：已发表的研究表明，可见波长反射和荧光光谱技术都是临床上识别易感斑块（VP）的有前途的技术，VP是一种容易破裂并产生动脉血栓的疾病。在正常的血管镜检查中已经可以看到反射，黄色脂质可以通过白色的纤维帽扩散，这取决于它的厚度，并形成VP的定性指示。通过定量光谱识别VP的临床有用仪器的进展需要一种基于动脉光纤的侧视探头（SLP）。第二阶段计划的主要目标是通过建立在第一阶段的组织探针光谱建模、开发探针构建技术和获得探针组织测量来实现这一目标。在二期项目中，将生产三种SLP设计，并在外周动脉中进行临床试验。数据将减少，以提供光谱分辨漫反射和本征荧光。将对同时进行蒙特卡罗建模的结果、病理结果和其他人的测量结果进行比较，以表征组织和识别具有显著脂质核心的薄纤维帽的病变- VP的标志。我们期望将比色信息与本征荧光相结合将产生比单独使用更好的结果。

DESCRIPTION (provided by applicant): Published studies indicate that visible wavelength reflectance and fluorescence spectroscopy are each promising techniques for clinically recognizing vulnerable plaque (VP) - a condition prone to rupture and produce arterial thrombosis. Reflectance is already visually accessible in normal angioscopy, and yellow lipid may be seen diffusely through an otherwise white fibrous cap, depending on its thickness, and form a qualitative indication for VP. Progress toward a clinically useful instrument for recognizing VP by quantified spectroscopy requires an arterial, optical-fiber based side-looking probe (SLP). It is a primary goal of the Phase-2 program to accomplish this by building on the Phase-1 tissue-probe-spectroscopy modeling, probe construction techniques developed, and probe - tissue measurements obtained. In the Phase-2 program three SLP designs will be produced and clinically tested in peripheral arteries. The data will be reduced to provide spectrally resolved diffuse reflectance and intrinsic fluorescence. Comparison will be made to results from concurrent Monte Carlo modeling, results from pathology, and results from the measurements of others with respect to characterizing the tissue and recognizing lesions with thin fibrous caps with a significant lipid core - hallmarks of VP. We expect that bringing together the colorimetry information with intrinsic fluorescence will produce results better than either alone.