Scanning Ocular Aberration Measurement (SAM) System

描述（由申请人提供）：项目概述：广泛的长期目标是开发一种扫描眼像差测量（SAM）系统，解决当前波前传感器的五个缺点。大部分或全部现行系统：1)过于昂贵，无法深入市场渗透，2)不能监测瞳孔大小和位置作为照明和调节的功能，3)不能在获得考试时动态改变调节需求，4)不允许根据所测量的像差结构的严重程度根据需要调整空间采样密度。5)用Zernike多项式拟合波前像差，但没有评估由此产生的平滑误差的影响，也没有提供替代的拟合方法。为弥补上述五个不足，第二阶段的具体目标是：开发地对空导弹系统硬件、开发地对空导弹系统软件、开发地对空导弹系统校准和测试项目，以及集成这些地对空导弹组件并进行系统级测试。SAM系统的商业应用包括临床测量，以支持定制视力矫正干预措施，如角膜激光手术、定制隐形眼镜和定制植入式镜片。该仪器还将能够为临床上困难的病例（如圆锥角膜或角膜移植）提供广泛的测量范围。实现了与健康的联系，因为一种具有成本效益的仪器，具有改进的效用，能够处理更广泛的患者，从而加快了将经过验证的实验室技术转移到临床护理。技术创新包括根据需要通过扫描微透镜阵列及其微孔径阵列进行可变空间采样，透明设计，以及作为环境照明和住宿功能的瞳孔位置监测。

DESCRIPTION (provided by applicant): 1. Project summary: The broad, long-term objective is to develop a Scanning ocular Aberration Measurement (SAM) system that solves five shortcomings of current wavefront sensors. Most or all current systems: 1) are too expensive for deep market penetration, 2) do not monitor the pupil size and location as a function of illumination and accommodation, 3) are not designed to change the accommodative demand dynamically as exams are acquired, 4) do not allow spatial sampling density to be adjusted as required depending upon the severity of the aberration structure being measured, and 5) fit the wavefront aberration with a Zernike polynomial without evaluating the impact of the resulting smoothing error and do not provide an alternative fitting method. To achieve the goal of meeting these 5 shortcomings, the specific aims for Phase II will be to: develop the SAM hardware, develop the SAM system software, develop the SAM system calibration and test items, and integrate these SAM components and perform a system level test. The commercial applications for the SAM system include clinical measurements to support custom vision correction interventions such as cornea laser surgery, custom contact lens, and custom implantable lenses. The instrument will also be able to provide an extended range of measurements for clinically difficult cases such as keratoconus or cornea transplants. Health relatedness is achieved in that a cost effective instrument with improved utility capable of handling a broader range of patients quickens the transfer of proven laboratory technology to clinical care. Technological innovations include a variable spatial sampling dependent on need by scanning a micro-lenslet array and its micro-aperture array, a see-through design, and pupil location monitoring as a function of ambient illumination and accommodation. 2. Relevance: The SAM system will provide a cost effective instrument capable of measuring a broader range of patient's ocular aberrations than is currently available. In addition, the ability to measure these aberrations dynamically while the eye is changing focus from a distant to a near object will be provided.