From Bench to Bedside: Molecular Stories of Research-Based Health Care

本项目的目标是开发探究式课程单元（ICU）， 分子结构的形式“分子的故事”的研究为基础的医疗保健。这些ICU将 由MSOE生物分子建模中心的工作人员组成的科学教育工作者团队开发 (CBM)，一位有着课程编写经验的资深教师，一位将 开发评估工具，以陪伴每个ICU，高中科学教师谁是 由于沉浸式的专业发展经验，熟悉ICU主题。 专业发展计划始于一个既定的夏季课程，基因，计划和 分子机器，更新了教师对分子机器基本概念的内容知识 结构和功能。这个夏季课程之后是为期一周的建模工作坊， 教师选择一个有趣的人类疾病，并探索疾病的分子基础，同时创造 受影响蛋白质的物理模型。在下一学年，教师将组织一个 SMART团队（学生建模研究主题）在他们的学校，并直接与一个基本的或 当地一所大学的临床研究人员创建了一个蛋白质的物理模型，作为药物靶点 治疗疾病在夏季之后，这种多组分，深入探索的分子基础， 一种疾病及其治疗，教师将参与ICU设计团队的成员。每个ICU 将遵循一个标准的调查驱动的格式，为学生提供机会，发现基本的 通过积极的，动手建模活动的分子结构的概念。然后将这些知识应用于 以一种强调批判性思维技能的方式来适应临床情况。 在这个项目中开发的ICU将在演示中广泛传播给其他教师 和研讨会由CBM的工作人员和参与教师，通过蛋白质建模给学生 威斯康星州科学奥林匹克竞赛的活动，在一个外展计划，以学生的密尔沃基男孩和 女孩俱乐部，并在我们当地的发现世界博物馆主办的一系列公开讲座的成人学习者。 每个ICU的共同主题是NIH支持的基础和临床研究在以下方面发挥的关键作用： 开发新的分子方法来治疗人类疾病。

The goal of this project is to develop Inquiry-based Curriculum Units (ICUs) that present basic concepts of molecular structure in the form of "molecular stories" of research-based health care. These ICUs will be developed by a team of science educators composed of staff of the MSOE Center for BioMolecular Modeling (CBM), a veteran teacher with curriculum writing experience, a science education researcher who will develop assessment instruments to accompany each ICU, and high school science teachers who are familiar with the ICU topic as a result of an immersive professional development experience. The professional development program begins with an established summer course, Genes, Schemes and Molecular Machines, which updates the teachers' content knowledge of basic concepts of molecular structure and function. This summer course is followed by a week-long Modeling Workshop in which teachers select an interesting human disease, and explore the molecular basis of the disease while creating physical models of the affected proteins. During the ensuing academic year, teachers will organize a SMART Team (Students Modeling A Research Topic) in their schools and interact directly with a basic or clinical researcher at a local university to create a physical model of the protein that serves as a drug target for the disease. In the summer following this multi-component, in-depth exploration of the molecular basis of a disease and its treatment, the teachers will participate as members of the ICU Design Team. Each ICU will follow a standard inquiry-driven format that provides opportunities for students to discover basic concepts of molecular structure through active, hands-on modeling activities. This knowledge is then applied to the clinical situation in a way that emphasizes critical thinking skills. The ICUs that are developed in this project will be broadly disseminated to other teachers in presentations and workshops given by CBM staff and the participating teachers, to students through a Protein Modeling event of the Wisconsin Science Olympiad , in an outreach program to students of the Milwaukee Boys & Girls Club, and to adult learners in a series of public lectures hosted by our local Discovery World Museum. The common theme of each ICU is the critical role played by NIH-supported basic and clinical research in the development of new molecular approaches to the treatment of human diseases.