CORE--CLINICAL

UCI ADRC临床核心的主要职能是：招募，表征， 作为我们对衰老和阿尔茨海默病的临床和神经生物学研究的一部分，纵向跟踪受试者，并通过为临床试验、遗传研究、组织库和成像协议提供良好特征的受试者，为所有参与UCI和全国衰老和AD研究的研究人员提供资源。通过这次更新，临床核心已经响应了RFA和我们的研究人员的需求，他们聚集了三组受试者，以检查与老年和唐氏综合征相关的认知状态。扩展我们之前的受试者队列（临床队列，N=250），核心研究增加了两个 特殊利益群体的主题。90+尸检队列（N=100）提供了独特的机会，以更好地了解大脑/行为的关系和人口中增长最快的部分，最古老的老年人老化的影响。我们的中心还为ADC系统带来了另一个独特的队列，成人唐氏综合征队列（N=75）。这些主题遵循与所有ADRC主题相同的方法，并为我们的基础和临床科学家提供创新研究的机会。除DS受试者（50%尸检参与率）和少数受试者外，要求所有ADRC受试者捐献大脑，并在入组时要求。我们积极努力增加尸检参与这些 科目临床核心，在神经病学，神经心理学和护理的专业知识，与所有ADRC核心，NACC，以及当地和国家的研究人员密切互动。临床核心支持ADRC的实验研究，为项目1提供受试者和临床数据，为项目2提供生物组织和临床数据，并为项目3的转基因研究中的比较研究提供人体数据。凭借我们独特的受试人群，ADRC临床核心为UCI和ADC系统带来了衰老和AD创新研究的中心资源。

The principal functions of the Clinical Core of the UCI ADRC are: to recruit, characterize, and longitudinally follow subjects as part of our clinical and neurobiological investigations of aging and Alzheimer's disease, and to provide a resource for all investigators involved in the study of aging and AD at UCI and nationally by providing well-characterized subjects for clinical trials, genetic studies, tissue repositories, and imaging protocols. With this renewal the Clinical Core has responded to the RFA and the needs of our investigators by assembling three cohorts of subjects to examine the cognitive states associated with old age and Down syndrome. Extending our previous cohort of subjects (the Clinical Cohort, N=250), the Core has added two special interest groups of subjects. The 90+ Autopsy Cohort (N=100) provides unique opportunities to better understand the brain/behavior relationships and effects of aging in the most rapidly growing segment of the population, the oldest old. Our center also brings to the ADC system another unique cohort, the adult Down Syndrome Cohort (N=75). These subjects are followed with the same methodology used for all ADRC subjects, and provide opportunities for innovative investigations by our basic and clinical scientists. Brain donation is requested from all ADRC subjects, and is required on enrollment, except for DS subjects (50% autopsy participation) and minorities. We aggressively work to increase autopsy participation in these subjects. The Clinical Core, with expertise in neurology, neuropsychology, and nursing, interacts closely with all ADRC cores, NACC, and local and national researchers. Supporting the ADRC's experimental studies, the Clinical Core provides subjects and clinical data to Project 1, biological tissues and clinical data to Project 2, and human data for comparison studies in the transgenic investigations of Project 3. With our unique subject populations, the ADRC Clinical Core brings to UCI and the ADC system a central resource for innovative studies of aging and AD.