Psychobiology of Trauma and Resilience Across Lifespan

描述（由申请人提供）：本申请为在加州好莱坞举行的第22届国际创伤应激研究学会（ISTSS）年会上的科学报告寻求资助。这次会议的主题是“生命中创伤和恢复力的心理生物学”。暴露于诸如儿童虐待、人际暴力、犯罪、灾难、恐怖主义和战争等潜在创伤性事件（pte）的发生率很高，并且暴露于这些事件会增加包括抑郁症、创伤后应激障碍和物质使用障碍在内的几种精神障碍的风险。在ISTSS年会上提出的报告旨在解决改善创伤应激研究和临床实践的几个障碍，包括：1)关于PTE研究类型的碎片化；2)缺乏从不同角度（如行为遗传学、社会心理、生物学）进行的创伤应激研究的结果和影响的知识；3)未考虑在生命的不同阶段经历的创伤性脑损伤对发育的影响；4)创伤应激研究人员对临床从业者的研究结果及其影响的翻译不佳。具体目标是：(1)组织一次会议，让学术、实践和政策受众参与讨论影响创伤压力、恢复力和创伤相关问题治疗的遗传、生物和社会心理因素，以努力教育这些不同的受众，并鼓励创新治疗和研究的发展；(2)整合社会心理和生物学的最新知识，以提高科学知识和科学知情的临床实践和倡导。在合作项目负责人和项目协调委员会的指导下，2006年年会大约20%的内容将致力于解决这些问题。主讲人是博士。Caspi和Moffitt，他们将强调使用基因x环境因素的行为遗传学方法来了解暴露于pte的风险和恢复能力。其他全体会议发言人将从社会心理和生物学角度讨论这些问题。主题演讲、全体会议和其他演讲将总结并发表在ISTSS网站上，关于这一主题的特别部分将发表在《创伤压力杂志》上。与达特新闻和创伤中心合作，将作出特别努力，使媒体报道研究结果及其影响。协调委员会将确保项目委员会的多样性，包括传统上代表性不足的妇女和种族/民族群体，演讲者之间也有类似的多样性。评估将包括从会议参与者那里获得调查反馈，汇编媒体报道数据，以及收集在JTS特别部分发表的文章的引用数据。在ISTSS年会上提出的报告旨在解决改善创伤应激研究和临床实践的几个障碍，包括：1)关于PTE研究类型的碎片化；2)缺乏从不同角度（如行为遗传学、社会心理、生物学）进行的创伤应激研究的结果和影响的知识；3)未考虑在生命的不同阶段经历的创伤性脑损伤对发育的影响；4)创伤应激研究人员对临床从业者的研究结果及其影响的翻译不佳。具体目标是：(1)组织一次会议，让学术、实践和政策受众参与讨论影响创伤压力、恢复力和创伤相关问题治疗的遗传、生物和社会心理因素，以努力教育这些不同的受众，并鼓励创新治疗和研究的发展；(2)整合社会心理和生物学的最新知识，以提高科学知识和科学知情的临床实践和倡导。

DESCRIPTION (provided by applicant): This application seeks funding for scientific presentations at the 22nd Annual Meeting of the International Society of Traumatic Stress Studies (ISTSS) in Hollywood, California. The theme of this meeting is "The Psychobiology of Trauma and Resilience Across the Lifespan." The prevalence of exposure to potentially traumatic events (PTEs) such as child maltreatment, interpersonal violence, crime, disasters, terrorism, and war is high, and exposure is demonstrated to increase risk of several mental disorders including depression, PTSD, and substance use disorders. The proposed presentations within the ISTSS Annual Meeting are designed to address several barriers to improved traumatic stress research and clinical practice that include: 1) fragmentation with respect to type of PTE studied; 2) lack of knowledge of findings and implications of traumatic stress research conducted from different perspectives (e.g., behavioral genetics, psychosocial, biological); 3) failure to consider the developmental impact of PTEs experienced at different points in the lifespan; and 4) poor translation of research findings and their implications from traumatic stress researchers to clinical practitioners. Specific aims are to: (1) organize a meeting that will engage academic, practice, and policy audiences in a discussion about the genetic, biological, and psychosocial factors that influence traumatic stress, resilience, and treatment of trauma-related problems in an effort to educate these disparate audiences and to encourage the development of innovative treatment and research; and (2) integrate psychosocial and biological state of the art knowledge to improve scientific knowledge and scientifically informed clinical practice and advocacy. Under the direction of the Co-PIs and a Project Coordinating Committee, approximately 20% of the 2006 Annual Meeting content will be devoted to addressing these issues. Keynote speakers are Drs. Caspi and Moffitt who will highlight behavioral genetic approaches towards using gene x environment factors to understand risk and resilience given exposure to PTEs. Other plenary speakers will address these issues from psychosocial and biological perspectives. Keynote, plenary, and other presentations will be summarized and published on the ISTSS website, and a Special Section on this topic will be published in the Journal of Traumatic Stress. In collaboration with the Dart Center for Journalism and Trauma, special efforts will be made to generate media coverage of research findings and their implications. The coordinating committee will insure that the program committee is diverse with respect to inclusion of women and racial/ethnic groups who are traditionally under represented, similar diversity among speakers. Evaluation will consist of obtaining survey feedback from meeting participants, compiling data on media coverage, and gathering citation data on articles published in the Special Section of JTS. The proposed presentations within the ISTSS Annual Meeting are designed to address several barriers to improved traumatic stress research and clinical practice that include: 1) fragmentation with respect to type of PTE studied; 2) lack of knowledge of findings and implications of traumatic stress research conducted from different perspectives (e.g., behavioral genetics, psychosocial, biological); 3) failure to consider the developmental impact of PTEs experienced at different points in the lifespan; and 4) poor translation of research findings and their implications from traumatic stress researchers to clinical practitioners. Specific aims are to: (1) organize a meeting that will engage academic, practice, and policy audiences in a discussion about the genetic, biological, and psychosocial factors that influence traumatic stress, resilience, and treatment of trauma-related problems in an effort to educate these disparate audiences and to encourage the development of innovative treatment and research; and (2) integrate psychosocial and biological state of the art knowledge to improve scientific knowledge and scientifically informed clinical practice and advocacy.